Post renal transplantation human herpesvirus 8-associated lymphoproliferative disorder and Kaposi's sarcoma

Joseph Kapelushnik, Samuel Ariad, Daniel Benharroch, Daniel Landau, Asher Moser, Georges Delsol, Pierre Brousset

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Post-transplantation lymphoproliferative disorders (PTLDs) and Kaposi's sarcoma (KS) are immunosuppression-related tumours developing in solid organ transplant patients. Although the Epstein-Barr virus (EBV) is detected in the majority of the PTLDs during the first year after transplantation, the proportion of EBV-negative PTLDs has increased in recent years. We report a case of a 17-year-old man who developed severe immune haemolytic anaemia, KS and human herpesvirus 8 (HHV-8)-associated, polymorphic-type PTLD 9 months after allogeneic renal transplantation from his HHV-8-seropositive father. It is suggested that: (i) HHV-8 may be associated with EBV-negative, polymorphous-type PTLD occurring less than 1 year after transplantation, and (ii) PTLD may be listed among other tumours, including KS, Castleman's disease and primary effusion lymphoma (PEL), that are related to HHV-8 infection.

Original languageEnglish
Pages (from-to)425-428
Number of pages4
JournalBritish Journal of Haematology
Volume113
Issue number2
DOIs
StatePublished - 21 Jun 2001
Externally publishedYes

Keywords

  • HHV-8
  • Human herpesvirus 8
  • Kaposi's sarcoma
  • PTLD
  • Post-transplantation lymphoproliferative disorder

Fingerprint

Dive into the research topics of 'Post renal transplantation human herpesvirus 8-associated lymphoproliferative disorder and Kaposi's sarcoma'. Together they form a unique fingerprint.

Cite this