Post renal transplantation human herpesvirus 8-associated lymphoproliferative disorder and Kaposi's sarcoma

Joseph Kapelushnik; Samuel Ariad; Daniel Benharroch; Daniel Landau; Asher Moser; Georges Delsol; Pierre Brousset

doi:10.1046/j.1365-2141.2001.02740.x

Post renal transplantation human herpesvirus 8-associated lymphoproliferative disorder and Kaposi's sarcoma

Joseph Kapelushnik, Samuel Ariad, Daniel Benharroch, Daniel Landau, Asher Moser, Georges Delsol, Pierre Brousset

Faculty of Health Sciences

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

Post-transplantation lymphoproliferative disorders (PTLDs) and Kaposi's sarcoma (KS) are immunosuppression-related tumours developing in solid organ transplant patients. Although the Epstein-Barr virus (EBV) is detected in the majority of the PTLDs during the first year after transplantation, the proportion of EBV-negative PTLDs has increased in recent years. We report a case of a 17-year-old man who developed severe immune haemolytic anaemia, KS and human herpesvirus 8 (HHV-8)-associated, polymorphic-type PTLD 9 months after allogeneic renal transplantation from his HHV-8-seropositive father. It is suggested that: (i) HHV-8 may be associated with EBV-negative, polymorphous-type PTLD occurring less than 1 year after transplantation, and (ii) PTLD may be listed among other tumours, including KS, Castleman's disease and primary effusion lymphoma (PEL), that are related to HHV-8 infection.

Original language	English
Pages (from-to)	425-428
Number of pages	4
Journal	British Journal of Haematology
Volume	113
Issue number	2
DOIs	https://doi.org/10.1046/j.1365-2141.2001.02740.x
State	Published - 21 Jun 2001

Keywords

HHV-8
Human herpesvirus 8
Kaposi's sarcoma
Post-transplantation lymphoproliferative disorder
PTLD

ASJC Scopus subject areas

Hematology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1046/j.1365-2141.2001.02740.x

Cite this

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title = "Post renal transplantation human herpesvirus 8-associated lymphoproliferative disorder and Kaposi's sarcoma",

abstract = "Post-transplantation lymphoproliferative disorders (PTLDs) and Kaposi's sarcoma (KS) are immunosuppression-related tumours developing in solid organ transplant patients. Although the Epstein-Barr virus (EBV) is detected in the majority of the PTLDs during the first year after transplantation, the proportion of EBV-negative PTLDs has increased in recent years. We report a case of a 17-year-old man who developed severe immune haemolytic anaemia, KS and human herpesvirus 8 (HHV-8)-associated, polymorphic-type PTLD 9 months after allogeneic renal transplantation from his HHV-8-seropositive father. It is suggested that: (i) HHV-8 may be associated with EBV-negative, polymorphous-type PTLD occurring less than 1 year after transplantation, and (ii) PTLD may be listed among other tumours, including KS, Castleman's disease and primary effusion lymphoma (PEL), that are related to HHV-8 infection.",

keywords = "HHV-8, Human herpesvirus 8, Kaposi's sarcoma, Post-transplantation lymphoproliferative disorder, PTLD",

author = "Joseph Kapelushnik and Samuel Ariad and Daniel Benharroch and Daniel Landau and Asher Moser and Georges Delsol and Pierre Brousset",

year = "2001",

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AU - Kapelushnik, Joseph

AU - Ariad, Samuel

AU - Benharroch, Daniel

AU - Landau, Daniel

AU - Moser, Asher

AU - Delsol, Georges

AU - Brousset, Pierre

PY - 2001/6/21

Y1 - 2001/6/21

N2 - Post-transplantation lymphoproliferative disorders (PTLDs) and Kaposi's sarcoma (KS) are immunosuppression-related tumours developing in solid organ transplant patients. Although the Epstein-Barr virus (EBV) is detected in the majority of the PTLDs during the first year after transplantation, the proportion of EBV-negative PTLDs has increased in recent years. We report a case of a 17-year-old man who developed severe immune haemolytic anaemia, KS and human herpesvirus 8 (HHV-8)-associated, polymorphic-type PTLD 9 months after allogeneic renal transplantation from his HHV-8-seropositive father. It is suggested that: (i) HHV-8 may be associated with EBV-negative, polymorphous-type PTLD occurring less than 1 year after transplantation, and (ii) PTLD may be listed among other tumours, including KS, Castleman's disease and primary effusion lymphoma (PEL), that are related to HHV-8 infection.

AB - Post-transplantation lymphoproliferative disorders (PTLDs) and Kaposi's sarcoma (KS) are immunosuppression-related tumours developing in solid organ transplant patients. Although the Epstein-Barr virus (EBV) is detected in the majority of the PTLDs during the first year after transplantation, the proportion of EBV-negative PTLDs has increased in recent years. We report a case of a 17-year-old man who developed severe immune haemolytic anaemia, KS and human herpesvirus 8 (HHV-8)-associated, polymorphic-type PTLD 9 months after allogeneic renal transplantation from his HHV-8-seropositive father. It is suggested that: (i) HHV-8 may be associated with EBV-negative, polymorphous-type PTLD occurring less than 1 year after transplantation, and (ii) PTLD may be listed among other tumours, including KS, Castleman's disease and primary effusion lymphoma (PEL), that are related to HHV-8 infection.

KW - HHV-8

KW - Human herpesvirus 8

KW - Kaposi's sarcoma

KW - Post-transplantation lymphoproliferative disorder

KW - PTLD

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M3 - Article

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SP - 425

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JF - British Journal of Haematology

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ER -

Post renal transplantation human herpesvirus 8-associated lymphoproliferative disorder and Kaposi's sarcoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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