Post-transcriptional regulation of gene expression in trypanosomes and leishmanias

Christine Clayton, Michal Shapira

Research output: Contribution to journalReview articlepeer-review

319 Scopus citations

Abstract

Gene expression in Kinetoplastids is very unusual in that the open reading frames are arranged in long polycistronic arrays, monocistronic mRNAs being created by post-transcriptional processing. Thus the regulation of gene expression is post-transcriptional. We here discuss recent results concerning the enzymes required for mRNA degradation, and components of the translation initiation machinery, and how both are regulated.

Original languageEnglish
Pages (from-to)93-101
Number of pages9
JournalMolecular and Biochemical Parasitology
Volume156
Issue number2
DOIs
StatePublished - 1 Dec 2007

Keywords

  • Degradation
  • Leishmania
  • Translation
  • Trypanosoma
  • mRNA

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