Postirradiation soft tissue sarcoma occurring in breast cancer patients: Report of seven cases and results of combination chemotherapy

Abraham Kuten; Dov Sapir; Yoram Cohen; Nissim Haim; Riva Borovik; Eliezer Robinson

doi:10.1002/jso.2930280304

Postirradiation soft tissue sarcoma occurring in breast cancer patients: Report of seven cases and results of combination chemotherapy

Abraham Kuten, Dov Sapir, Yoram Cohen, Nissim Haim, Riva Borovik, Eliezer Robinson

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

Seven cases of soft tissue sarcoma developing after primary or postoperative radiotherapy for breast carcinoma are reported. The sarcomas occurred within the irradiated volume, after a latent period of 4‐26 years. These cases conform well to established criteria for the diagnosis of radiation‐induced sarcoma. Chemotherapy, consisting of the four‐drug combination CYVAD1C (cyclophosphamide, vincristine, adriamycin, DTIC) was employed in six of the seven patients. Only two of them achieved partial remission, lasting only 2 and 3 months, respectively. The effectiveness of adriamycin‐containing chemotherapy regimens in soft tissue sarcomas as well as the remote hazard of radiation‐related sarcoma in primary or postoperative breast irradiation are discussed.

Original language	English
Pages (from-to)	168-171
Number of pages	4
Journal	Journal of Surgical Oncology
Volume	28
Issue number	3
DOIs	https://doi.org/10.1002/jso.2930280304
State	Published - 1 Jan 1985
Externally published	Yes

Keywords

CYVADIC
chemotherapy
radiation side effects
radiation‐induced soft tissue sarcoma

ASJC Scopus subject areas

Surgery
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jso.2930280304

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title = "Postirradiation soft tissue sarcoma occurring in breast cancer patients: Report of seven cases and results of combination chemotherapy",

abstract = "Seven cases of soft tissue sarcoma developing after primary or postoperative radiotherapy for breast carcinoma are reported. The sarcomas occurred within the irradiated volume, after a latent period of 4‐26 years. These cases conform well to established criteria for the diagnosis of radiation‐induced sarcoma. Chemotherapy, consisting of the four‐drug combination CYVAD1C (cyclophosphamide, vincristine, adriamycin, DTIC) was employed in six of the seven patients. Only two of them achieved partial remission, lasting only 2 and 3 months, respectively. The effectiveness of adriamycin‐containing chemotherapy regimens in soft tissue sarcomas as well as the remote hazard of radiation‐related sarcoma in primary or postoperative breast irradiation are discussed.",

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T2 - Report of seven cases and results of combination chemotherapy

AU - Kuten, Abraham

AU - Sapir, Dov

AU - Cohen, Yoram

AU - Haim, Nissim

AU - Borovik, Riva

AU - Robinson, Eliezer

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N2 - Seven cases of soft tissue sarcoma developing after primary or postoperative radiotherapy for breast carcinoma are reported. The sarcomas occurred within the irradiated volume, after a latent period of 4‐26 years. These cases conform well to established criteria for the diagnosis of radiation‐induced sarcoma. Chemotherapy, consisting of the four‐drug combination CYVAD1C (cyclophosphamide, vincristine, adriamycin, DTIC) was employed in six of the seven patients. Only two of them achieved partial remission, lasting only 2 and 3 months, respectively. The effectiveness of adriamycin‐containing chemotherapy regimens in soft tissue sarcomas as well as the remote hazard of radiation‐related sarcoma in primary or postoperative breast irradiation are discussed.

AB - Seven cases of soft tissue sarcoma developing after primary or postoperative radiotherapy for breast carcinoma are reported. The sarcomas occurred within the irradiated volume, after a latent period of 4‐26 years. These cases conform well to established criteria for the diagnosis of radiation‐induced sarcoma. Chemotherapy, consisting of the four‐drug combination CYVAD1C (cyclophosphamide, vincristine, adriamycin, DTIC) was employed in six of the seven patients. Only two of them achieved partial remission, lasting only 2 and 3 months, respectively. The effectiveness of adriamycin‐containing chemotherapy regimens in soft tissue sarcomas as well as the remote hazard of radiation‐related sarcoma in primary or postoperative breast irradiation are discussed.

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Postirradiation soft tissue sarcoma occurring in breast cancer patients: Report of seven cases and results of combination chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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