Abstract
Seven cases of soft tissue sarcoma developing after primary or postoperative radiotherapy for breast carcinoma are reported. The sarcomas occurred within the irradiated volume, after a latent period of 4‐26 years. These cases conform well to established criteria for the diagnosis of radiation‐induced sarcoma. Chemotherapy, consisting of the four‐drug combination CYVAD1C (cyclophosphamide, vincristine, adriamycin, DTIC) was employed in six of the seven patients. Only two of them achieved partial remission, lasting only 2 and 3 months, respectively. The effectiveness of adriamycin‐containing chemotherapy regimens in soft tissue sarcomas as well as the remote hazard of radiation‐related sarcoma in primary or postoperative breast irradiation are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 168-171 |
| Number of pages | 4 |
| Journal | Journal of Surgical Oncology |
| Volume | 28 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1 Jan 1985 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- CYVADIC
- chemotherapy
- radiation side effects
- radiation‐induced soft tissue sarcoma
ASJC Scopus subject areas
- Surgery
- Oncology
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