Postirradiation soft tissue sarcoma occurring in breast cancer patients: Report of seven cases and results of combination chemotherapy

Abraham Kuten; Dov Sapir; Yoram Cohen; Nissim Haim; Riva Borovik; Eliezer Robinson

doi:10.1002/jso.2930280304

Postirradiation soft tissue sarcoma occurring in breast cancer patients: Report of seven cases and results of combination chemotherapy

Abraham Kuten
, Dov Sapir
, Yoram Cohen
, Nissim Haim
, Riva Borovik
, Eliezer Robinson

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

Seven cases of soft tissue sarcoma developing after primary or postoperative radiotherapy for breast carcinoma are reported. The sarcomas occurred within the irradiated volume, after a latent period of 4‐26 years. These cases conform well to established criteria for the diagnosis of radiation‐induced sarcoma. Chemotherapy, consisting of the four‐drug combination CYVAD1C (cyclophosphamide, vincristine, adriamycin, DTIC) was employed in six of the seven patients. Only two of them achieved partial remission, lasting only 2 and 3 months, respectively. The effectiveness of adriamycin‐containing chemotherapy regimens in soft tissue sarcomas as well as the remote hazard of radiation‐related sarcoma in primary or postoperative breast irradiation are discussed.

Original language	English
Pages (from-to)	168-171
Number of pages	4
Journal	Journal of Surgical Oncology
Volume	28
Issue number	3
DOIs	https://doi.org/10.1002/jso.2930280304
State	Published - 1 Jan 1985
Externally published	Yes

Keywords

CYVADIC
chemotherapy
radiation side effects
radiation‐induced soft tissue sarcoma

ASJC Scopus subject areas

Surgery
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jso.2930280304

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title = "Postirradiation soft tissue sarcoma occurring in breast cancer patients: Report of seven cases and results of combination chemotherapy",

abstract = "Seven cases of soft tissue sarcoma developing after primary or postoperative radiotherapy for breast carcinoma are reported. The sarcomas occurred within the irradiated volume, after a latent period of 4‐26 years. These cases conform well to established criteria for the diagnosis of radiation‐induced sarcoma. Chemotherapy, consisting of the four‐drug combination CYVAD1C (cyclophosphamide, vincristine, adriamycin, DTIC) was employed in six of the seven patients. Only two of them achieved partial remission, lasting only 2 and 3 months, respectively. The effectiveness of adriamycin‐containing chemotherapy regimens in soft tissue sarcomas as well as the remote hazard of radiation‐related sarcoma in primary or postoperative breast irradiation are discussed.",

keywords = "CYVADIC, chemotherapy, radiation side effects, radiation‐induced soft tissue sarcoma",

author = "Abraham Kuten and Dov Sapir and Yoram Cohen and Nissim Haim and Riva Borovik and Eliezer Robinson",

year = "1985",

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doi = "10.1002/jso.2930280304",

language = "English",

volume = "28",

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T1 - Postirradiation soft tissue sarcoma occurring in breast cancer patients

T2 - Report of seven cases and results of combination chemotherapy

AU - Kuten, Abraham

AU - Sapir, Dov

AU - Cohen, Yoram

AU - Haim, Nissim

AU - Borovik, Riva

AU - Robinson, Eliezer

PY - 1985/1/1

Y1 - 1985/1/1

N2 - Seven cases of soft tissue sarcoma developing after primary or postoperative radiotherapy for breast carcinoma are reported. The sarcomas occurred within the irradiated volume, after a latent period of 4‐26 years. These cases conform well to established criteria for the diagnosis of radiation‐induced sarcoma. Chemotherapy, consisting of the four‐drug combination CYVAD1C (cyclophosphamide, vincristine, adriamycin, DTIC) was employed in six of the seven patients. Only two of them achieved partial remission, lasting only 2 and 3 months, respectively. The effectiveness of adriamycin‐containing chemotherapy regimens in soft tissue sarcomas as well as the remote hazard of radiation‐related sarcoma in primary or postoperative breast irradiation are discussed.

AB - Seven cases of soft tissue sarcoma developing after primary or postoperative radiotherapy for breast carcinoma are reported. The sarcomas occurred within the irradiated volume, after a latent period of 4‐26 years. These cases conform well to established criteria for the diagnosis of radiation‐induced sarcoma. Chemotherapy, consisting of the four‐drug combination CYVAD1C (cyclophosphamide, vincristine, adriamycin, DTIC) was employed in six of the seven patients. Only two of them achieved partial remission, lasting only 2 and 3 months, respectively. The effectiveness of adriamycin‐containing chemotherapy regimens in soft tissue sarcomas as well as the remote hazard of radiation‐related sarcoma in primary or postoperative breast irradiation are discussed.

KW - CYVADIC

KW - chemotherapy

KW - radiation side effects

KW - radiation‐induced soft tissue sarcoma

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DO - 10.1002/jso.2930280304

M3 - Article

AN - SCOPUS:0021918509

SN - 0022-4790

VL - 28

SP - 168

EP - 171

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

IS - 3

ER -

Postirradiation soft tissue sarcoma occurring in breast cancer patients: Report of seven cases and results of combination chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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