Postnatal exposure to diisopropylfluorophosphate enhances discrimination learning in adult mice

Ora Kofman, Tal Sher

Research output: Contribution to journalArticlepeer-review


Visual discrimination and reversal learning were tested in adult C57Bl/6 mice that had been treated on postnatal days (PND) 4-10 with diisopropylfluorophosphate (DFP), an acetylcholinesterase inhibitor. DFP-treated mice attained the learning criterion in the Y maze significantly earlier than saline-treated mice. Female mice treated with DFP showed a more rapid decline in errors in the initial discrimination task, compared to female mice treated with saline. There was no effect of DFP treatment on learning the reverse discrimination. The data suggest that long-lasting effects of treatment with an acetylcholinesterase inhibitor can improve discrimination learning, similarly to the improvement reported by acute administration in adults.

Original languageEnglish
Pages (from-to)914-918
Number of pages5
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Issue number5
StatePublished - 1 Jul 2006


  • Acetylcholine
  • Diisopropylfluorophosphate
  • Discrimination learning
  • Postnatal

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry


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