Potassium leak channels and the KCNK family of two-p-domain subunits

Steve A.N. Goldstein, Detlef Bockenhauer, Ita O’Kelly, Noam Zilberberg

Research output: Contribution to journalArticlepeer-review

539 Scopus citations

Abstract

With a bang, a new family of potassium channels has exploded into view. Although KCNK channels were discovered only five years ago, they already outnumber other channel types. KCNK channels are easy to identify because of their unique structure — they possess two pore-forming domains in each subunit. The new channels function in a most remarkable fashion: they are highly regulated, potassium-selective leak channels. Although leak currents are fundamental to the function of nerves and muscles, the molecular basis for this type of conductance had been a mystery. Here we review the discovery of KCNK channels, what has been learned about them and what lies ahead. Even though two-P-domain channels are widespread and essential, they were hidden from sight in plain view — our most basic questions remain to be answered.

Original languageEnglish
Pages (from-to)175-184
Number of pages10
JournalNature Reviews Neuroscience
Volume2
Issue number3
DOIs
StatePublished - 1 Jan 2001
Externally publishedYes

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