Potential implications of matrix metalloproteinase-9 in assessment and treatment of coronary artery disease

Yuval Konstantino, Tu T. Nguyen, Robert Wolk, Robert J. Aiello, Steven G. Terra, David A. Fryburg

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Background: Matrix metalloproteinase (MMP)-9, a member of the MMP superfamily is consistently implicated in the pathophysiology of atherosclerosis and plaque rupture, the most common mechanism responsible for acute coronary syndrome (ACS). Aim: To summarize the role of MMP-9 in atherosclerosis and its potential implications in assessment and treatment of coronary artery disease (CAD). Methods: We reviewed the PubMed database for relevant data regarding the role of MMP-9 in the pathophysiology of atherosclerosis. In the light of these data, we postulate potential implications of MMP-9 in the management and treatment of CAD. Results and conclusions: Existing data strongly support the role of MMP-9 in plaque destabilization and rupture. Based on the current knowledge, MMP-9 can potentially serve as a diagnostic biomarker in ACS and a prognostic biomarker in ACS and chronic CAD patients. MMP-9 is reduced by therapies that are associated with favourable outcome in atherosclerosis and thus may serve as a surrogate biomarker of treatment efficacy. However, large morbidity and mortality trials are still required to confirm that MMP-9 reduction is associated with improved outcome independent of the traditional risk factors (i.e. low-density lipoprotein cholesterol). Given its role in plaque rupture, inhibition of MMP-9 may promote plaque stabilization and consequently reduce cardiovascular events. Yet, the efficacy and safety of MMPs inhibitors should be first studied in preclinical models of atherosclerosis.

Original languageEnglish
Pages (from-to)118-129
Number of pages12
JournalBiomarkers
Volume14
Issue number2
DOIs
StatePublished - 1 Mar 2009
Externally publishedYes

Keywords

  • Acute coronary syndrome
  • Atherosclerosis
  • MMP inhibitors
  • MMP-9
  • MMPs

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

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