TY - JOUR
T1 - Potential role of arteether on N-methyl-D-aspartate (NMDA) receptor expression in experimental cerebral malaria mice and extension of their survival
AU - Singh, Sunil Kumar
AU - Dwivedi, Hemlata
AU - Gunjan, Sarika
AU - Chauhan, Bhavana Singh
AU - Pandey, Swaroop Kumar
AU - Tripathi, Renu
N1 - Publisher Copyright:
© 2019 Cambridge University Press.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Cerebral malaria (CM) is the severe neurological complication causing acute non-traumatic encephalopathy in tropical countries. The mechanisms underlying the fatal cerebral complications are still not fully understood. Glutamate, a major excitatory neurotransmitter in the central nervous system of the mammalian brain, plays a key role in the development of neuronal cells, motor function, synaptic plasticity, learning and memory processes under normal physiological conditions. The subtypes of ionotropic glutamate receptor are N-methyl-D-aspartate receptors (NMDARs) which are involved in cellular mechanisms of learning and memory, synaptic plasticity and also mediate excitotoxic neuronal injury. In the present study, we found that glutamate level in synaptosomes, as well as expression of NMDAR, was elevated during the extreme condition of CM in C57BL6 mice. Arteether at 50 mg kg-1 × 1, 25 mg kg-1 × 2, days decreased the NMDAR expression and increased the overall survival of the experimental CM mice.
AB - Cerebral malaria (CM) is the severe neurological complication causing acute non-traumatic encephalopathy in tropical countries. The mechanisms underlying the fatal cerebral complications are still not fully understood. Glutamate, a major excitatory neurotransmitter in the central nervous system of the mammalian brain, plays a key role in the development of neuronal cells, motor function, synaptic plasticity, learning and memory processes under normal physiological conditions. The subtypes of ionotropic glutamate receptor are N-methyl-D-aspartate receptors (NMDARs) which are involved in cellular mechanisms of learning and memory, synaptic plasticity and also mediate excitotoxic neuronal injury. In the present study, we found that glutamate level in synaptosomes, as well as expression of NMDAR, was elevated during the extreme condition of CM in C57BL6 mice. Arteether at 50 mg kg-1 × 1, 25 mg kg-1 × 2, days decreased the NMDAR expression and increased the overall survival of the experimental CM mice.
KW - Arteether
KW - NMDA receptor
KW - Plasmodium berghei ANKA
KW - cerebral malaria
KW - glutamate
UR - http://www.scopus.com/inward/record.url?scp=85068256428&partnerID=8YFLogxK
U2 - 10.1017/S0031182019000878
DO - 10.1017/S0031182019000878
M3 - Article
C2 - 31244453
AN - SCOPUS:85068256428
SN - 0031-1820
VL - 146
SP - 1571
EP - 1577
JO - Parasitology
JF - Parasitology
IS - 12
ER -