Power spectrum analysis and cardiovascular morbidity in anxiety disorders

Hagit Cohen, Jonathan Benjamin

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations


Spectral analysis of heart rate variability (HRV) and related measures has been shown to be a reliable noninvasive technique enabling quantitative assessment of cardiovascular autonomic regulatory responses to autonomic regulatory mechanisms; it provides a dynamic probe of sympathetic and parasympathetic tone, reflecting the interactions between the two. Over 20 studies reported abnormalities of HRV in anxiety, and patients with heart disease and anxiety are at increased risk for morbidity and mortality. Psychiatric drugs partly correct abnormalities of HRV and, recently, autonomic drugs (β-blockers) have been studied in anxiety disorders. The authors call for further studies, especially in patients with co-existing anxiety disorders and heart disease, incorporating assessment of HRV.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalAutonomic Neuroscience: Basic and Clinical
Issue number1-2
StatePublished - 30 Jul 2006
Externally publishedYes


  • Anxiety disorder
  • Autonomic nervous system (ANS)
  • Cardiovascular diseases
  • Heart rate variability (HRV)
  • Power spectrum analysis (PSA)

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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