PP060-SUN HEPATIC FAT IS DIFFERENTIALLY-ASSOCIATED WITH SUPERFICIAL VERSUS DEEP ABDOMINAL SUBCUTANEOUS ADIPOSE TISSUES SUB-DEPOTS; MRI IMAGING STUDY

N. Cohen, Ilan Shelef, D. Schwarzfuchs, Yftach Gepner, Elad Shemesh, O. Tangi-Rosental, E. Goshen, M. Lerner, N. Bril, D. Serfaty, S. Kanisboch, Yoash Chassidim, Rachel Golan, S. Witkow, Dror Dicker, Yaakov Henkin, M.J. Stampfer, Assaf Rudich, Iris Shai

Research output: Contribution to journalMeeting Abstract

Abstract

Rationale: The association of hepatic fat with different
abdominal fat sub-depots is controversial.
Methods: We evaluated the association of hepatic fat percent
(HFP) with abdominal fat sub-depots by 3-T MRI imaging
among 261 participants. HFP was evaluated by region-ofinterest method. Abdominal fat distribution was analyzed at
L5-L4 level.
Results: Across the participants (age= 47.6 years, 31 women)
men [HFP= 10.8%, Waist circumference (WC)= 107.7 cm, visceral adipose tissue (VAT)= 28.9%, deep subcutaneous adipose tissue (DSAT)= 45.4%, superficial SAT (SSAT)= 23.6%] had
higher HFP than women [HFP= 6.4%, WC= 99.4 cm, VAT= 20.1%,
DSAT= 38%, SSAT= 38.1%; p = 0.001). In multivariate regression
model %VAT (beta= 0.315;p < 0.001) and %DSAT (beta= 0.13;
p = 0.044) were independently and directly associated with
hepatic fat but not with %SSAT (beta= 0.036; p = 0.569).
Further independent predictors were TG (beta= 0.204;
p < 0.001), HDL-c (beta= 0.129; p = 0.023) and serum ALT
levels (beta= 0.307; p < 0.001).
Conclusion: While visceral and DSAT abdominal fat are
independently related to increased HFP, SSAT remains neutral,
suggesting differential roles of abdominal fat sub-depots with
liver pathophysiology.
Original languageEnglish
Pages (from-to)S44
JournalClinical Nutrition
Volume32
DOIs
StatePublished - 1 Sep 2013

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