PP060-SUN HEPATIC FAT IS DIFFERENTIALLY-ASSOCIATED WITH SUPERFICIAL VERSUS DEEP ABDOMINAL SUBCUTANEOUS ADIPOSE TISSUES SUB-DEPOTS; MRI IMAGING STUDY

N. Cohen; Ilan Shelef; D. Schwarzfuchs; Yftach Gepner; Elad Shemesh; O. Tangi-Rosental; E. Goshen; M. Lerner; N. Bril; D. Serfaty; S. Kanisboch; Yoash Chassidim; Rachel Golan; Dror Dicker; Yaakov Henkin; M.J. Stampfer; Assaf Rudich; Iris Shai

doi:10.1016/S0261-5614(13)60105-3

PP060-SUN HEPATIC FAT IS DIFFERENTIALLY-ASSOCIATED WITH SUPERFICIAL VERSUS DEEP ABDOMINAL SUBCUTANEOUS ADIPOSE TISSUES SUB-DEPOTS; MRI IMAGING STUDY

N. Cohen, Ilan Shelef, D. Schwarzfuchs, Yftach Gepner, Elad Shemesh, O. Tangi-Rosental, E. Goshen, M. Lerner, N. Bril, D. Serfaty, S. Kanisboch, Yoash Chassidim, Rachel Golan, Dror Dicker, Yaakov Henkin, M.J. Stampfer, Assaf Rudich, Iris Shai

Research output: Contribution to journal › Meeting Abstract

Abstract

Rationale: The association of hepatic fat with different
abdominal fat sub-depots is controversial.
Methods: We evaluated the association of hepatic fat percent
(HFP) with abdominal fat sub-depots by 3-T MRI imaging
among 261 participants. HFP was evaluated by region-ofinterest method. Abdominal fat distribution was analyzed at
L5-L4 level.
Results: Across the participants (age= 47.6 years, 31 women)
men [HFP= 10.8%, Waist circumference (WC)= 107.7 cm, visceral adipose tissue (VAT)= 28.9%, deep subcutaneous adipose tissue (DSAT)= 45.4%, superficial SAT (SSAT)= 23.6%] had
higher HFP than women [HFP= 6.4%, WC= 99.4 cm, VAT= 20.1%,
DSAT= 38%, SSAT= 38.1%; p = 0.001). In multivariate regression
model %VAT (beta= 0.315;p < 0.001) and %DSAT (beta= 0.13;
p = 0.044) were independently and directly associated with
hepatic fat but not with %SSAT (beta= 0.036; p = 0.569).
Further independent predictors were TG (beta= 0.204;
p < 0.001), HDL-c (beta= 0.129; p = 0.023) and serum ALT
levels (beta= 0.307; p < 0.001).
Conclusion: While visceral and DSAT abdominal fat are
independently related to increased HFP, SSAT remains neutral,
suggesting differential roles of abdominal fat sub-depots with
liver pathophysiology.

Original language	English
Pages (from-to)	S44
Journal	Clinical Nutrition
Volume	32
DOIs	https://doi.org/10.1016/S0261-5614(13)60105-3
State	Published - 1 Sep 2013

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Cohen, N., Shelef, I., Schwarzfuchs, D., Gepner, Y., Shemesh, E., Tangi-Rosental, O., Goshen, E., Lerner, M., Bril, N., Serfaty, D., Kanisboch, S., Chassidim, Y., Golan, R., Dicker, D., Henkin, Y., Stampfer, M. J., Rudich, A., & Shai, I. (2013). PP060-SUN HEPATIC FAT IS DIFFERENTIALLY-ASSOCIATED WITH SUPERFICIAL VERSUS DEEP ABDOMINAL SUBCUTANEOUS ADIPOSE TISSUES SUB-DEPOTS; MRI IMAGING STUDY. Clinical Nutrition, 32, S44. https://doi.org/10.1016/S0261-5614(13)60105-3

@article{dbf15b9a1541452da076258763956ba5,

title = "PP060-SUN HEPATIC FAT IS DIFFERENTIALLY-ASSOCIATED WITH SUPERFICIAL VERSUS DEEP ABDOMINAL SUBCUTANEOUS ADIPOSE TISSUES SUB-DEPOTS; MRI IMAGING STUDY",

abstract = "Rationale: The association of hepatic fat with differentabdominal fat sub-depots is controversial.Methods: We evaluated the association of hepatic fat percent(HFP) with abdominal fat sub-depots by 3-T MRI imagingamong 261 participants. HFP was evaluated by region-ofinterest method. Abdominal fat distribution was analyzed atL5-L4 level.Results: Across the participants (age= 47.6 years, 31 women)men [HFP= 10.8%, Waist circumference (WC)= 107.7 cm, visceral adipose tissue (VAT)= 28.9%, deep subcutaneous adipose tissue (DSAT)= 45.4%, superficial SAT (SSAT)= 23.6%] hadhigher HFP than women [HFP= 6.4%, WC= 99.4 cm, VAT= 20.1%,DSAT= 38%, SSAT= 38.1%; p = 0.001). In multivariate regressionmodel %VAT (beta= 0.315;p < 0.001) and %DSAT (beta= 0.13;p = 0.044) were independently and directly associated withhepatic fat but not with %SSAT (beta= 0.036; p = 0.569).Further independent predictors were TG (beta= 0.204;p < 0.001), HDL-c (beta= 0.129; p = 0.023) and serum ALTlevels (beta= 0.307; p < 0.001).Conclusion: While visceral and DSAT abdominal fat areindependently related to increased HFP, SSAT remains neutral,suggesting differential roles of abdominal fat sub-depots withliver pathophysiology.",

author = "N. Cohen and Ilan Shelef and D. Schwarzfuchs and Yftach Gepner and Elad Shemesh and O. Tangi-Rosental and E. Goshen and M. Lerner and N. Bril and D. Serfaty and S. Kanisboch and Yoash Chassidim and Rachel Golan and Dror Dicker and Yaakov Henkin and M.J. Stampfer and Assaf Rudich and Iris Shai",

year = "2013",

month = sep,

day = "1",

doi = "10.1016/S0261-5614(13)60105-3",

language = "English",

volume = "32",

pages = "S44",

journal = "Clinical Nutrition",

issn = "0261-5614",

publisher = "Churchill Livingstone",

}

Cohen, N, Shelef, I, Schwarzfuchs, D, Gepner, Y, Shemesh, E, Tangi-Rosental, O, Goshen, E, Lerner, M, Bril, N, Serfaty, D, Kanisboch, S, Chassidim, Y, Golan, R, Dicker, D, Henkin, Y, Stampfer, MJ, Rudich, A & Shai, I 2013, 'PP060-SUN HEPATIC FAT IS DIFFERENTIALLY-ASSOCIATED WITH SUPERFICIAL VERSUS DEEP ABDOMINAL SUBCUTANEOUS ADIPOSE TISSUES SUB-DEPOTS; MRI IMAGING STUDY', Clinical Nutrition, vol. 32, pp. S44. https://doi.org/10.1016/S0261-5614(13)60105-3

TY - JOUR

T1 - PP060-SUN HEPATIC FAT IS DIFFERENTIALLY-ASSOCIATED WITH SUPERFICIAL VERSUS DEEP ABDOMINAL SUBCUTANEOUS ADIPOSE TISSUES SUB-DEPOTS; MRI IMAGING STUDY

AU - Cohen, N.

AU - Shelef, Ilan

AU - Schwarzfuchs, D.

AU - Gepner, Yftach

AU - Shemesh, Elad

AU - Tangi-Rosental, O.

AU - Goshen, E.

AU - Lerner, M.

AU - Bril, N.

AU - Serfaty, D.

AU - Kanisboch, S.

AU - Chassidim, Yoash

AU - Golan, Rachel

AU - Dicker, Dror

AU - Henkin, Yaakov

AU - Stampfer, M.J.

AU - Rudich, Assaf

AU - Shai, Iris

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Rationale: The association of hepatic fat with differentabdominal fat sub-depots is controversial.Methods: We evaluated the association of hepatic fat percent(HFP) with abdominal fat sub-depots by 3-T MRI imagingamong 261 participants. HFP was evaluated by region-ofinterest method. Abdominal fat distribution was analyzed atL5-L4 level.Results: Across the participants (age= 47.6 years, 31 women)men [HFP= 10.8%, Waist circumference (WC)= 107.7 cm, visceral adipose tissue (VAT)= 28.9%, deep subcutaneous adipose tissue (DSAT)= 45.4%, superficial SAT (SSAT)= 23.6%] hadhigher HFP than women [HFP= 6.4%, WC= 99.4 cm, VAT= 20.1%,DSAT= 38%, SSAT= 38.1%; p = 0.001). In multivariate regressionmodel %VAT (beta= 0.315;p < 0.001) and %DSAT (beta= 0.13;p = 0.044) were independently and directly associated withhepatic fat but not with %SSAT (beta= 0.036; p = 0.569).Further independent predictors were TG (beta= 0.204;p < 0.001), HDL-c (beta= 0.129; p = 0.023) and serum ALTlevels (beta= 0.307; p < 0.001).Conclusion: While visceral and DSAT abdominal fat areindependently related to increased HFP, SSAT remains neutral,suggesting differential roles of abdominal fat sub-depots withliver pathophysiology.

AB - Rationale: The association of hepatic fat with differentabdominal fat sub-depots is controversial.Methods: We evaluated the association of hepatic fat percent(HFP) with abdominal fat sub-depots by 3-T MRI imagingamong 261 participants. HFP was evaluated by region-ofinterest method. Abdominal fat distribution was analyzed atL5-L4 level.Results: Across the participants (age= 47.6 years, 31 women)men [HFP= 10.8%, Waist circumference (WC)= 107.7 cm, visceral adipose tissue (VAT)= 28.9%, deep subcutaneous adipose tissue (DSAT)= 45.4%, superficial SAT (SSAT)= 23.6%] hadhigher HFP than women [HFP= 6.4%, WC= 99.4 cm, VAT= 20.1%,DSAT= 38%, SSAT= 38.1%; p = 0.001). In multivariate regressionmodel %VAT (beta= 0.315;p < 0.001) and %DSAT (beta= 0.13;p = 0.044) were independently and directly associated withhepatic fat but not with %SSAT (beta= 0.036; p = 0.569).Further independent predictors were TG (beta= 0.204;p < 0.001), HDL-c (beta= 0.129; p = 0.023) and serum ALTlevels (beta= 0.307; p < 0.001).Conclusion: While visceral and DSAT abdominal fat areindependently related to increased HFP, SSAT remains neutral,suggesting differential roles of abdominal fat sub-depots withliver pathophysiology.

U2 - 10.1016/S0261-5614(13)60105-3

DO - 10.1016/S0261-5614(13)60105-3

M3 - Meeting Abstract

SN - 0261-5614

VL - 32

SP - S44

JO - Clinical Nutrition

JF - Clinical Nutrition

ER -

PP060-SUN HEPATIC FAT IS DIFFERENTIALLY-ASSOCIATED WITH SUPERFICIAL VERSUS DEEP ABDOMINAL SUBCUTANEOUS ADIPOSE TISSUES SUB-DEPOTS; MRI IMAGING STUDY

Abstract

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