PP119-MON EFFECT OF MODERATE ALCOHOL INTAKE ON 24-H BLOOD PRESSURE DYNAMICS AMONG PATIENTS WITH TYPE 2 DIABETES

Yftach Gepner; D. Schwarzfuchs; Rachel Golan; Yaakov Henkin; Ilana Harman-Boehm; O. Tangi-Rosental; Ilan Shelef; E. Goshen; B. Sarusi; Lena Novack; Michael Friger; N. Cohen; N. Bril; M. Lerner; D. Serfaty; Assaf Rudich; M.J. Stampfer; Iris Shai

doi:10.1016/S0261-5614(13)60430-6

Abstract

AIMS Observational studies report inconsistent associations between moderate alcohol intake and blood pressure (BP). In a sub-study of a larger randomized controlled trial, we assessed the effect of initiating moderate red wine consumption on 24-h BP recordings and the effect of a common genetic variant of alcohol dehydrogenases (ADH) among patients with type 2 diabetes. METHODS Fifty-four type 2 diabetes, alcohol abstainers were randomized to consume 150 ml/dinner dry red wine or mineral water. Both groups were guided to adhere to a Mediterranean diet, without caloric restriction. We measured 24-h ambulatory BP monitoring (ABPM) at baseline and after 6 months. RESULTS Participants (age = 57 years; 85% men; mean 24-h BP = 129/77 mm Hg) had 92% 6-month retention. After 6 months of intervention, the average 24-h BP did not differ between the wine and water groups. A transient decrease in BP was observed in the red wine group at midnight (3–4 hours after wine intake: systolic BP: red wine = −10.6 mm Hg vs. mineral water = +2.3 mm Hg; P = 0.031) and the following morning at 7–9 am (red wine: −6.2 mm Hg vs. mineral water: +5.6 mm Hg; P = 0.014). In a second post hoc sub-analysis among the red wine consumers, individuals who were homozygous for the gene encoding ADH1B*2 variant (Arg48His; rs1229984, TT, fast ethanol metabolizers), exhibited a reduction in mean 24-h systolic BP (−8.0 mm Hg vs. +3.7mm Hg; P = 0.002) and pulse pressure (−3.8 mm Hg vs. +1.2 mm Hg; P = 0.032) compared to heterozygotes and those homozygous for the ADH1B*1 variant (CC, slow metabolizers). CONCLUSIONS Initiating moderate red wine consumption at dinner among type 2 diabetes patients does not have a discernable effect on mean 24-h BP. Yet, a modest temporal BP reduction could be documented, and a more pronounced BP-lowering effect is suggested among fast ethanol metabolizers. clinical trials registration ClinicalTrials.gov Identifier: NCT00784433.

Original language	English
Pages (from-to)	S166
Journal	Clinical Nutrition
Volume	32
DOIs	https://doi.org/10.1016/S0261-5614(13)60430-6
State	Published - 1 Sep 2013

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Gepner, Y., Schwarzfuchs, D., Golan, R., Henkin, Y., Harman-Boehm, I., Tangi-Rosental, O., Shelef, I., Goshen, E., Sarusi, B., Novack, L., Friger, M., Cohen, N., Bril, N., Lerner, M., Serfaty, D., Rudich, A., Stampfer, M. J., & Shai, I. (2013). PP119-MON EFFECT OF MODERATE ALCOHOL INTAKE ON 24-H BLOOD PRESSURE DYNAMICS AMONG PATIENTS WITH TYPE 2 DIABETES. Clinical Nutrition, 32, S166. https://doi.org/10.1016/S0261-5614(13)60430-6

@article{5dfc1274248a49789a290119e78eeb63,

title = "PP119-MON EFFECT OF MODERATE ALCOHOL INTAKE ON 24-H BLOOD PRESSURE DYNAMICS AMONG PATIENTS WITH TYPE 2 DIABETES",

abstract = "AIMS Observational studies report inconsistent associations between moderate alcohol intake and blood pressure (BP). In a sub-study of a larger randomized controlled trial, we assessed the effect of initiating moderate red wine consumption on 24-h BP recordings and the effect of a common genetic variant of alcohol dehydrogenases (ADH) among patients with type 2 diabetes. METHODS Fifty-four type 2 diabetes, alcohol abstainers were randomized to consume 150 ml/dinner dry red wine or mineral water. Both groups were guided to adhere to a Mediterranean diet, without caloric restriction. We measured 24-h ambulatory BP monitoring (ABPM) at baseline and after 6 months. RESULTS Participants (age = 57 years; 85% men; mean 24-h BP = 129/77 mm Hg) had 92% 6-month retention. After 6 months of intervention, the average 24-h BP did not differ between the wine and water groups. A transient decrease in BP was observed in the red wine group at midnight (3–4 hours after wine intake: systolic BP: red wine = −10.6 mm Hg vs. mineral water = +2.3 mm Hg; P = 0.031) and the following morning at 7–9 am (red wine: −6.2 mm Hg vs. mineral water: +5.6 mm Hg; P = 0.014). In a second post hoc sub-analysis among the red wine consumers, individuals who were homozygous for the gene encoding ADH1B*2 variant (Arg48His; rs1229984, TT, fast ethanol metabolizers), exhibited a reduction in mean 24-h systolic BP (−8.0 mm Hg vs. +3.7mm Hg; P = 0.002) and pulse pressure (−3.8 mm Hg vs. +1.2 mm Hg; P = 0.032) compared to heterozygotes and those homozygous for the ADH1B*1 variant (CC, slow metabolizers). CONCLUSIONS Initiating moderate red wine consumption at dinner among type 2 diabetes patients does not have a discernable effect on mean 24-h BP. Yet, a modest temporal BP reduction could be documented, and a more pronounced BP-lowering effect is suggested among fast ethanol metabolizers. clinical trials registration ClinicalTrials.gov Identifier: NCT00784433.",

author = "Yftach Gepner and D. Schwarzfuchs and Rachel Golan and Yaakov Henkin and Ilana Harman-Boehm and O. Tangi-Rosental and Ilan Shelef and E. Goshen and B. Sarusi and Lena Novack and Michael Friger and N. Cohen and N. Bril and M. Lerner and D. Serfaty and Assaf Rudich and M.J. Stampfer and Iris Shai",

year = "2013",

month = sep,

day = "1",

doi = "10.1016/S0261-5614(13)60430-6",

language = "English",

volume = "32",

pages = "S166",

journal = "Clinical Nutrition",

issn = "0261-5614",

publisher = "Churchill Livingstone",

}

Gepner, Y, Schwarzfuchs, D, Golan, R, Henkin, Y, Harman-Boehm, I, Tangi-Rosental, O, Shelef, I, Goshen, E, Sarusi, B, Novack, L, Friger, M, Cohen, N, Bril, N, Lerner, M, Serfaty, D, Rudich, A, Stampfer, MJ & Shai, I 2013, 'PP119-MON EFFECT OF MODERATE ALCOHOL INTAKE ON 24-H BLOOD PRESSURE DYNAMICS AMONG PATIENTS WITH TYPE 2 DIABETES', Clinical Nutrition, vol. 32, pp. S166. https://doi.org/10.1016/S0261-5614(13)60430-6

TY - JOUR

T1 - PP119-MON EFFECT OF MODERATE ALCOHOL INTAKE ON 24-H BLOOD PRESSURE DYNAMICS AMONG PATIENTS WITH TYPE 2 DIABETES

AU - Gepner, Yftach

AU - Schwarzfuchs, D.

AU - Golan, Rachel

AU - Henkin, Yaakov

AU - Harman-Boehm, Ilana

AU - Tangi-Rosental, O.

AU - Shelef, Ilan

AU - Goshen, E.

AU - Sarusi, B.

AU - Novack, Lena

AU - Friger, Michael

AU - Cohen, N.

AU - Bril, N.

AU - Lerner, M.

AU - Serfaty, D.

AU - Rudich, Assaf

AU - Stampfer, M.J.

AU - Shai, Iris

PY - 2013/9/1

Y1 - 2013/9/1

N2 - AIMS Observational studies report inconsistent associations between moderate alcohol intake and blood pressure (BP). In a sub-study of a larger randomized controlled trial, we assessed the effect of initiating moderate red wine consumption on 24-h BP recordings and the effect of a common genetic variant of alcohol dehydrogenases (ADH) among patients with type 2 diabetes. METHODS Fifty-four type 2 diabetes, alcohol abstainers were randomized to consume 150 ml/dinner dry red wine or mineral water. Both groups were guided to adhere to a Mediterranean diet, without caloric restriction. We measured 24-h ambulatory BP monitoring (ABPM) at baseline and after 6 months. RESULTS Participants (age = 57 years; 85% men; mean 24-h BP = 129/77 mm Hg) had 92% 6-month retention. After 6 months of intervention, the average 24-h BP did not differ between the wine and water groups. A transient decrease in BP was observed in the red wine group at midnight (3–4 hours after wine intake: systolic BP: red wine = −10.6 mm Hg vs. mineral water = +2.3 mm Hg; P = 0.031) and the following morning at 7–9 am (red wine: −6.2 mm Hg vs. mineral water: +5.6 mm Hg; P = 0.014). In a second post hoc sub-analysis among the red wine consumers, individuals who were homozygous for the gene encoding ADH1B*2 variant (Arg48His; rs1229984, TT, fast ethanol metabolizers), exhibited a reduction in mean 24-h systolic BP (−8.0 mm Hg vs. +3.7mm Hg; P = 0.002) and pulse pressure (−3.8 mm Hg vs. +1.2 mm Hg; P = 0.032) compared to heterozygotes and those homozygous for the ADH1B*1 variant (CC, slow metabolizers). CONCLUSIONS Initiating moderate red wine consumption at dinner among type 2 diabetes patients does not have a discernable effect on mean 24-h BP. Yet, a modest temporal BP reduction could be documented, and a more pronounced BP-lowering effect is suggested among fast ethanol metabolizers. clinical trials registration ClinicalTrials.gov Identifier: NCT00784433.

AB - AIMS Observational studies report inconsistent associations between moderate alcohol intake and blood pressure (BP). In a sub-study of a larger randomized controlled trial, we assessed the effect of initiating moderate red wine consumption on 24-h BP recordings and the effect of a common genetic variant of alcohol dehydrogenases (ADH) among patients with type 2 diabetes. METHODS Fifty-four type 2 diabetes, alcohol abstainers were randomized to consume 150 ml/dinner dry red wine or mineral water. Both groups were guided to adhere to a Mediterranean diet, without caloric restriction. We measured 24-h ambulatory BP monitoring (ABPM) at baseline and after 6 months. RESULTS Participants (age = 57 years; 85% men; mean 24-h BP = 129/77 mm Hg) had 92% 6-month retention. After 6 months of intervention, the average 24-h BP did not differ between the wine and water groups. A transient decrease in BP was observed in the red wine group at midnight (3–4 hours after wine intake: systolic BP: red wine = −10.6 mm Hg vs. mineral water = +2.3 mm Hg; P = 0.031) and the following morning at 7–9 am (red wine: −6.2 mm Hg vs. mineral water: +5.6 mm Hg; P = 0.014). In a second post hoc sub-analysis among the red wine consumers, individuals who were homozygous for the gene encoding ADH1B*2 variant (Arg48His; rs1229984, TT, fast ethanol metabolizers), exhibited a reduction in mean 24-h systolic BP (−8.0 mm Hg vs. +3.7mm Hg; P = 0.002) and pulse pressure (−3.8 mm Hg vs. +1.2 mm Hg; P = 0.032) compared to heterozygotes and those homozygous for the ADH1B*1 variant (CC, slow metabolizers). CONCLUSIONS Initiating moderate red wine consumption at dinner among type 2 diabetes patients does not have a discernable effect on mean 24-h BP. Yet, a modest temporal BP reduction could be documented, and a more pronounced BP-lowering effect is suggested among fast ethanol metabolizers. clinical trials registration ClinicalTrials.gov Identifier: NCT00784433.

U2 - 10.1016/S0261-5614(13)60430-6

DO - 10.1016/S0261-5614(13)60430-6

M3 - Meeting Abstract

SN - 0261-5614

VL - 32

SP - S166

JO - Clinical Nutrition

JF - Clinical Nutrition

ER -

PP119-MON EFFECT OF MODERATE ALCOHOL INTAKE ON 24-H BLOOD PRESSURE DYNAMICS AMONG PATIENTS WITH TYPE 2 DIABETES

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