PPh3·HBr-DMSO: A Reagent System for Diverse Chemoselective Transformations

Kanchan Mal, Amanpreet Kaur, Fazle Haque, Indrajit Das

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

The broad applicability of the hitherto unexplored reagent combination PPh3·HBr-DMSO is exemplified with multiple highly diverse one-step transformations to synthetically useful building blocks, such as flavones, 4H-thiochromen-4-ones, α-hydroxy ketones, 1,4-naphthoquinones (including vitamin K3), 2-bromo-3-substituted-1H-1-indenones, 2-methylthio-1H-1-indenones, 3-butyne-1,2-dione, and 4-pentene-2,3-diones. The simple and mild reaction conditions make the reagent superior in terms of yield and substrate scope in comparison with the existing alternatives.

Original languageEnglish
Pages (from-to)6400-6410
Number of pages11
JournalJournal of Organic Chemistry
Volume80
Issue number12
DOIs
StatePublished - 19 Jun 2015
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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