TY - JOUR
T1 - PPh3·HBr-DMSO
T2 - A Reagent System for Diverse Chemoselective Transformations
AU - Mal, Kanchan
AU - Kaur, Amanpreet
AU - Haque, Fazle
AU - Das, Indrajit
N1 - Publisher Copyright:
© 2015 American Chemical Society.
PY - 2015/6/19
Y1 - 2015/6/19
N2 - The broad applicability of the hitherto unexplored reagent combination PPh3·HBr-DMSO is exemplified with multiple highly diverse one-step transformations to synthetically useful building blocks, such as flavones, 4H-thiochromen-4-ones, α-hydroxy ketones, 1,4-naphthoquinones (including vitamin K3), 2-bromo-3-substituted-1H-1-indenones, 2-methylthio-1H-1-indenones, 3-butyne-1,2-dione, and 4-pentene-2,3-diones. The simple and mild reaction conditions make the reagent superior in terms of yield and substrate scope in comparison with the existing alternatives.
AB - The broad applicability of the hitherto unexplored reagent combination PPh3·HBr-DMSO is exemplified with multiple highly diverse one-step transformations to synthetically useful building blocks, such as flavones, 4H-thiochromen-4-ones, α-hydroxy ketones, 1,4-naphthoquinones (including vitamin K3), 2-bromo-3-substituted-1H-1-indenones, 2-methylthio-1H-1-indenones, 3-butyne-1,2-dione, and 4-pentene-2,3-diones. The simple and mild reaction conditions make the reagent superior in terms of yield and substrate scope in comparison with the existing alternatives.
UR - http://www.scopus.com/inward/record.url?scp=84934936146&partnerID=8YFLogxK
U2 - 10.1021/acs.joc.5b00846
DO - 10.1021/acs.joc.5b00846
M3 - Article
AN - SCOPUS:84934936146
SN - 0022-3263
VL - 80
SP - 6400
EP - 6410
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 12
ER -