Pre-eclampsia and future female malignancy

Asnat Walfisch, Roy Kessous, Ehud Davidson, Ruslan Sergienko, Eyal Sheiner

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective: To investigate an association between pre-eclampsia and future genital tract and breast malignancies. Methods: The incidence of genital tract and breast malignancies was compared in a cohort of women with and without a history of pre-eclampsia. Cumulative incidence was assessed using a Kaplan-Meier survival curve. Results: During the study period, 103 180 deliveries met the inclusion criteria; 8.1% occurred in patients with pre-eclampsia. Patients with pre-eclampsia did not have a significantly different risk of genital tract or breast malignancies. The results remained insignificant in a sub-analysis based on malignancy type, pre-eclampsia severity and number of episodes per patient. No difference in cumulative incidence was demonstrated. Conclusion: Pre-eclampsia does not appear to influence the risk of future genital tract or breast malignancies.

Original languageEnglish
Pages (from-to)456-463
Number of pages8
JournalHypertension in Pregnancy
Issue number4
StatePublished - 2 Oct 2015
Externally publishedYes


  • Breast cancer
  • Genital malignancy
  • Gestational hypertension
  • Long-term follow up
  • Pregnancy


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