Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth

Yan Li; Lisa Elmén; Igor Segota; Yibo Xian; Roberto Tinoco; Yongmei Feng; Yu Fujita; Rafael R. Segura Muñoz; Robert Schmaltz; Linda M. Bradley; Amanda Ramer-Tait; Raphy Zarecki; Tao Long; Scott N. Peterson; Ze'ev A. Ronai

doi:10.1016/j.celrep.2020.01.035

Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth

Yan Li, Lisa Elmén, Igor Segota, Yibo Xian, Roberto Tinoco, Yongmei Feng, Yu Fujita, Rafael R. Segura Muñoz, Robert Schmaltz, Linda M. Bradley, Amanda Ramer-Tait, Raphy Zarecki, Tao Long, Scott N. Peterson, Ze'ev A. Ronai

Research output: Contribution to journal › Article › peer-review

115 Scopus citations

Abstract

Li et al. show that the gut microbiota effect on anti-tumor immunity is affected by inulin or mucin, prebiotics that inhibit melanoma and colon cancer growth in syngeneic models and attenuate melanoma resistance to MEKi. These studies highlight a potential therapeutic role for prebiotics in shaping the microbiota composition to promote anti-tumor immunity.

Original language	English
Pages (from-to)	1753-1766.e6
Journal	Cell Reports
Volume	30
Issue number	6
DOIs	https://doi.org/10.1016/j.celrep.2020.01.035
State	Published - 11 Feb 2020
Externally published	Yes

Keywords

MEK inhibitor
anti-tumor immunity
colon cancer
gut microbiota
inulin
melanoma
mucin
prebiotics
therapy resistance

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.celrep.2020.01.035

Cite this

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title = "Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth",

abstract = "Li et al. show that the gut microbiota effect on anti-tumor immunity is affected by inulin or mucin, prebiotics that inhibit melanoma and colon cancer growth in syngeneic models and attenuate melanoma resistance to MEKi. These studies highlight a potential therapeutic role for prebiotics in shaping the microbiota composition to promote anti-tumor immunity.",

keywords = "MEK inhibitor, anti-tumor immunity, colon cancer, gut microbiota, inulin, melanoma, mucin, prebiotics, therapy resistance",

author = "Yan Li and Lisa Elm{\'e}n and Igor Segota and Yibo Xian and Roberto Tinoco and Yongmei Feng and Yu Fujita and {Segura Mu{\~n}oz}, {Rafael R.} and Robert Schmaltz and Bradley, {Linda M.} and Amanda Ramer-Tait and Raphy Zarecki and Tao Long and Peterson, {Scott N.} and Ronai, {Ze'ev A.}",

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year = "2020",

month = feb,

day = "11",

doi = "10.1016/j.celrep.2020.01.035",

language = "English",

volume = "30",

pages = "1753--1766.e6",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

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TY - JOUR

T1 - Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth

AU - Li, Yan

AU - Elmén, Lisa

AU - Segota, Igor

AU - Xian, Yibo

AU - Tinoco, Roberto

AU - Feng, Yongmei

AU - Fujita, Yu

AU - Segura Muñoz, Rafael R.

AU - Schmaltz, Robert

AU - Bradley, Linda M.

AU - Ramer-Tait, Amanda

AU - Zarecki, Raphy

AU - Long, Tao

AU - Peterson, Scott N.

AU - Ronai, Ze'ev A.

PY - 2020/2/11

Y1 - 2020/2/11

N2 - Li et al. show that the gut microbiota effect on anti-tumor immunity is affected by inulin or mucin, prebiotics that inhibit melanoma and colon cancer growth in syngeneic models and attenuate melanoma resistance to MEKi. These studies highlight a potential therapeutic role for prebiotics in shaping the microbiota composition to promote anti-tumor immunity.

AB - Li et al. show that the gut microbiota effect on anti-tumor immunity is affected by inulin or mucin, prebiotics that inhibit melanoma and colon cancer growth in syngeneic models and attenuate melanoma resistance to MEKi. These studies highlight a potential therapeutic role for prebiotics in shaping the microbiota composition to promote anti-tumor immunity.

KW - MEK inhibitor

KW - anti-tumor immunity

KW - colon cancer

KW - gut microbiota

KW - inulin

KW - melanoma

KW - mucin

KW - prebiotics

KW - therapy resistance

UR - http://www.scopus.com/inward/record.url?scp=85079195435&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2020.01.035

DO - 10.1016/j.celrep.2020.01.035

M3 - Article

C2 - 32049008

AN - SCOPUS:85079195435

SN - 2211-1247

VL - 30

SP - 1753-1766.e6

JO - Cell Reports

JF - Cell Reports

IS - 6

ER -

Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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