Prebiotic selection of the AT base-pair? A physical organic approach to understanding AT base-pair stability indicates special stability (1,2)

Jordan R. Quinn; Steven C. Zimmerman; Janet E. Del Bene; Isaiah Shavitt

doi:10.1021/bk-2009-1025.ch005

Prebiotic selection of the AT base-pair? A physical organic approach to understanding AT base-pair stability indicates special stability (1,2)

Jordan R. Quinn, Steven C. Zimmerman, Janet E. Del Bene, Isaiah Shavitt

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The A·T and G·C base-pairs have been investigated experimentally and computationally to examine whether they contain any special stability relative to other base pairs. An empirically based relationship between overall complex stability (-ΔG°) and various possible component interactions is developed to probe the question in a large set of experimentally determined base-pairs and their analogs. Unexpected stability is observed in the A·T pair, and its origin is examined computationally. The results and their possible relationship to prebiotic chemistry are described.

Original language	English
Pages (from-to)	95-107
Number of pages	13
Journal	ACS Symposium Series
Volume	1025
DOIs	https://doi.org/10.1021/bk-2009-1025.ch005
State	Published - 20 Dec 2009
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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10.1021/bk-2009-1025.ch005

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abstract = "The A·T and G·C base-pairs have been investigated experimentally and computationally to examine whether they contain any special stability relative to other base pairs. An empirically based relationship between overall complex stability (-ΔG°) and various possible component interactions is developed to probe the question in a large set of experimentally determined base-pairs and their analogs. Unexpected stability is observed in the A·T pair, and its origin is examined computationally. The results and their possible relationship to prebiotic chemistry are described.",

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AU - Quinn, Jordan R.

AU - Zimmerman, Steven C.

AU - Del Bene, Janet E.

AU - Shavitt, Isaiah

PY - 2009/12/20

Y1 - 2009/12/20

N2 - The A·T and G·C base-pairs have been investigated experimentally and computationally to examine whether they contain any special stability relative to other base pairs. An empirically based relationship between overall complex stability (-ΔG°) and various possible component interactions is developed to probe the question in a large set of experimentally determined base-pairs and their analogs. Unexpected stability is observed in the A·T pair, and its origin is examined computationally. The results and their possible relationship to prebiotic chemistry are described.

AB - The A·T and G·C base-pairs have been investigated experimentally and computationally to examine whether they contain any special stability relative to other base pairs. An empirically based relationship between overall complex stability (-ΔG°) and various possible component interactions is developed to probe the question in a large set of experimentally determined base-pairs and their analogs. Unexpected stability is observed in the A·T pair, and its origin is examined computationally. The results and their possible relationship to prebiotic chemistry are described.

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JO - ACS Symposium Series

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ER -

Prebiotic selection of the AT base-pair? A physical organic approach to understanding AT base-pair stability indicates special stability (1,2)

Abstract

ASJC Scopus subject areas

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