The A·T and G·C base-pairs have been investigated experimentally and computationally to examine whether they contain any special stability relative to other base pairs. An empirically based relationship between overall complex stability (-ΔG°) and various possible component interactions is developed to probe the question in a large set of experimentally determined base-pairs and their analogs. Unexpected stability is observed in the A·T pair, and its origin is examined computationally. The results and their possible relationship to prebiotic chemistry are described.
|Number of pages||13|
|Journal||ACS Symposium Series|
|State||Published - 20 Dec 2009|
ASJC Scopus subject areas
- Chemistry (all)
- Chemical Engineering (all)