Preconceptional antibiotic treatment to prevent preterm birth in women with a previous preterm delivery

Jimmy Espinoza, Offer Erez, Roberto Romero

Research output: Contribution to journalReview articlepeer-review

82 Scopus citations


This article addresses the question of whether the uterine cavity is normally sterile and reviews the difficulties in conducting microbiologic studies of the endometrium, the limitations of conventional microbiologic techniques (cultivation-dependent), and the potential contribution of molecular microbiology to examine microbial diversity and burden of the endometrium. Issues pertaining to the diagnosis of chronic endometritis and the need for information about the prognostic value of this finding in subsequent pregnancies are discussed. The results of a randomized clinical trial of antibiotic administration versus placebo in women with a previous preterm birth are reviewed and commentary is provided. The emerging picture is that microbial-host interactions in the endometrial cavity are important for reproductive success. This is a US government work. There are no restrictions on its use.

Original languageEnglish
Pages (from-to)630-637
Number of pages8
JournalAmerican Journal of Obstetrics and Gynecology
Issue number3
StatePublished - 1 Mar 2006
Externally publishedYes


  • Bacterial vaginosis
  • Infection
  • Preterm birth

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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