Predicting drug characteristics using biomedical text embedding

Guy Shtar, Asnat Greenstein-Messica, Eyal Mazuz, Lior Rokach, Bracha Shapira

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Drug–drug interactions (DDIs) are preventable causes of medical injuries and often result in doctor and emergency room visits. Previous research demonstrates the effectiveness of using matrix completion approaches based on known drug interactions to predict unknown Drug–drug interactions. However, in the case of a new drug, where there is limited or no knowledge regarding the drug’s existing interactions, such an approach is unsuitable, and other drug’s preferences can be used to accurately predict new Drug–drug interactions. Methods: We propose adjacency biomedical text embedding (ABTE) to address this limitation by using a hybrid approach which combines known drugs’ interactions and the drug’s biomedical text embeddings to predict the DDIs of both new and well known drugs. Results: Our evaluation demonstrates the superiority of this approach compared to recently published DDI prediction models and matrix factorization-based approaches. Furthermore, we compared the use of different text embedding methods in ABTE, and found that the concept embedding approach, which involves biomedical information in the embedding process, provides the highest performance for this task. Additionally, we demonstrate the effectiveness of leveraging biomedical text embedding for additional drugs’ biomedical prediction task by presenting text embedding’s contribution to a multi-modal pregnancy drug safety classification. Conclusion: Text and concept embeddings created by analyzing a domain-specific large-scale biomedical corpora can be used for predicting drug-related properties such as Drug–drug interactions and drug safety prediction. Prediction models based on the embeddings resulted in comparable results to hand-crafted features, however text embeddings do not require manual categorization or data collection and rely solely on the published literature.

Original languageEnglish
Article number526
JournalBMC Bioinformatics
Volume23
Issue number1
DOIs
StatePublished - 7 Dec 2022

Keywords

  • Drug interactions
  • Machine learning
  • Text mining

ASJC Scopus subject areas

  • Applied Mathematics
  • Molecular Biology
  • Structural Biology
  • Biochemistry
  • Computer Science Applications

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