TY - JOUR
T1 - Predictors for incidence and remission of NAFLD in the general population during a seven-year prospective follow-up
AU - Zelber-Sagi, Shira
AU - Lotan, Roni
AU - Shlomai, Amir
AU - Webb, Muriel
AU - Harrari, Gil
AU - Buch, Assaf
AU - Nitzan Kaluski, Dorit
AU - Halpern, Zamir
AU - Oren, Ran
PY - 2012/5/1
Y1 - 2012/5/1
N2 - Background & Aims: Data on the incidence and remission rates of non-alcoholic fatty liver disease (NAFLD) as well as predictive factors are scant. This study aims at evaluating NAFLD's epidemiology in prospective follow-up of individuals sampled from the general population. Methods: Evaluation of metabolic parameters and ultrasonographic evidence of NAFLD was performed in 213 subjects, with no known liver disease or history of alcohol abuse. The evaluation was performed at baseline and after a 7-year period by identical protocols. Results: Of the 147 patients who did not have NAFLD at baseline, 28 (19%) were found to have NAFLD at a 7-year follow-up. Baseline BMI, HOMA score, blood cholesterol, triglycerides, leptin levels, and weight gain (5.8 ± 6.1 vs. 1.4 ± 5.5 kg, p <0.001) were significantly higher and adiponectin was lower among those who developed NAFLD at 7-year follow-up, compared with those who remained NAFLD-free. However, only weight gain and baseline HOMA were independent predictors for the development of NAFLD. Of the 66 patients who were found to have NAFLD at baseline, as many as 24 patients (36.4%) had no evidence of NAFLD at 7 years. Weight loss of 2.7 ± 5.0 kg was significantly associated with NAFLD remission. Moreover, there was a 75% remission rate among NAFLD patients who lost 5% or more from their baseline weight. Conclusions: Among the general population, weight gain, and baseline insulin resistance are predictors for NAFLD incidence. One third of NAFLD patients may have remission of disease within a 7-year follow-up, mostly depending on modest weight reduction.
AB - Background & Aims: Data on the incidence and remission rates of non-alcoholic fatty liver disease (NAFLD) as well as predictive factors are scant. This study aims at evaluating NAFLD's epidemiology in prospective follow-up of individuals sampled from the general population. Methods: Evaluation of metabolic parameters and ultrasonographic evidence of NAFLD was performed in 213 subjects, with no known liver disease or history of alcohol abuse. The evaluation was performed at baseline and after a 7-year period by identical protocols. Results: Of the 147 patients who did not have NAFLD at baseline, 28 (19%) were found to have NAFLD at a 7-year follow-up. Baseline BMI, HOMA score, blood cholesterol, triglycerides, leptin levels, and weight gain (5.8 ± 6.1 vs. 1.4 ± 5.5 kg, p <0.001) were significantly higher and adiponectin was lower among those who developed NAFLD at 7-year follow-up, compared with those who remained NAFLD-free. However, only weight gain and baseline HOMA were independent predictors for the development of NAFLD. Of the 66 patients who were found to have NAFLD at baseline, as many as 24 patients (36.4%) had no evidence of NAFLD at 7 years. Weight loss of 2.7 ± 5.0 kg was significantly associated with NAFLD remission. Moreover, there was a 75% remission rate among NAFLD patients who lost 5% or more from their baseline weight. Conclusions: Among the general population, weight gain, and baseline insulin resistance are predictors for NAFLD incidence. One third of NAFLD patients may have remission of disease within a 7-year follow-up, mostly depending on modest weight reduction.
KW - Hepatorenal index
KW - Insulin resistance
KW - Predictors
KW - Ultrasonography
KW - Weight change
UR - http://www.scopus.com/inward/record.url?scp=84859705556&partnerID=8YFLogxK
U2 - 10.1016/j.jhep.2011.12.011
DO - 10.1016/j.jhep.2011.12.011
M3 - Article
C2 - 22245895
AN - SCOPUS:84859705556
SN - 0168-8278
VL - 56
SP - 1145
EP - 1151
JO - Journal of Hepatology
JF - Journal of Hepatology
IS - 5
ER -
