TY - JOUR
T1 - Predictors of serum 25(Oh)D increase following bimonthly supplementation with 100,000 IU vitamin D in healthy, men aged 25-65 years
AU - Tepper, Sigal
AU - Shahar, Danit R.
AU - Geva, Diklah
AU - Ish-Shalom, Sofia
N1 - Funding Information:
Predictors for increase in serum 25(OH)D were evaluated in a 12-month vitamin D supplementation trial of healthy men (aged 25–65) with serum 25 (OH) < 20 ng/ml. Participants were recruited during their annual periodic examinations at the Rambam Medical Center in Haifa, Israel, and via the study's website. The study was approved by the Rambam Health Care Campus review board and registered in ClinicalTrials.gov as NCT01016184 and funded by a grant from The Preventive Action, Safety & Health Administration, Ministry of Industry, Trade and Labor, Israel. Participants were supplemented with 100,000 IU vitamin D bimonthly (1666 IU/day in aqueous solution (manufactured by Frutarom Ltd for the health division of Maabarot Products). Clinical and laboratory evaluations were performed at time of inclusion and after 6 and 12 months. Weight, height and waist circumference were recorded D .
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Vitamin D replenishment therapy typically entails standard dosages, but related increases in serum 25(OH)D levels vary between individuals. This study was aimed to identify factors that affect the efficacy of vitamin D supplementation. Subjects and methods 79 healthy men aged 25-65 with 25(OH)D < 20 ng/ml participated in a vitamin D supplementation study. All participants received 100,000 IU vitamin D bimonthly, e.g., 1666 IU/day. Personal and demographic information, physical activity and sun-exposure questionnaires were completed by the participants. Weight, height, and waist circumference were recorded. Serum calcium, creatinine, 25(OH)D, PTH, lipid profile, and liver-enzyme levels were assessed. All measurements were repeated after 6 and 12 months. The difference between baseline serum 25(OH)D and 12-month measurements was calculated (delta). Linear regression was performed to identify predictors for increases in 25(OH)D levels. Results Mean serum 25(OH)D level increases according to BMI were 12.6 ± 5.29 ng/ml for BMI ≠25, 10.12 ± 4.95 ng/ml for 25 < BMI 30, and only 6.39 ;plusmn 5.33 ng/ml for BMI 30, which differed significantly from the other BMI categories (p = 0.003). In a regression model to predict 25(OH)D increase, BMI was the main predictor (p ;< 0.001), explaining 21.6% of the variance in serum 25(OH)D (inverse association). Age, sun-exposure, serum cholesterol, physical-activity, baseline 25(OH)D levels and seasonality were insignificant. The full model explained 27.9% of the variance in serum 25(OH)D. Conclusion This study's main findings are that BMI affect vitamin D response in healthy men. Quantitative supplementation adjustments may be warranted in obese men, for whom the dose may need to be doubled. This article is part of a special issue entitled '16th Vitamin D Workshop'.
AB - Vitamin D replenishment therapy typically entails standard dosages, but related increases in serum 25(OH)D levels vary between individuals. This study was aimed to identify factors that affect the efficacy of vitamin D supplementation. Subjects and methods 79 healthy men aged 25-65 with 25(OH)D < 20 ng/ml participated in a vitamin D supplementation study. All participants received 100,000 IU vitamin D bimonthly, e.g., 1666 IU/day. Personal and demographic information, physical activity and sun-exposure questionnaires were completed by the participants. Weight, height, and waist circumference were recorded. Serum calcium, creatinine, 25(OH)D, PTH, lipid profile, and liver-enzyme levels were assessed. All measurements were repeated after 6 and 12 months. The difference between baseline serum 25(OH)D and 12-month measurements was calculated (delta). Linear regression was performed to identify predictors for increases in 25(OH)D levels. Results Mean serum 25(OH)D level increases according to BMI were 12.6 ± 5.29 ng/ml for BMI ≠25, 10.12 ± 4.95 ng/ml for 25 < BMI 30, and only 6.39 ;plusmn 5.33 ng/ml for BMI 30, which differed significantly from the other BMI categories (p = 0.003). In a regression model to predict 25(OH)D increase, BMI was the main predictor (p ;< 0.001), explaining 21.6% of the variance in serum 25(OH)D (inverse association). Age, sun-exposure, serum cholesterol, physical-activity, baseline 25(OH)D levels and seasonality were insignificant. The full model explained 27.9% of the variance in serum 25(OH)D. Conclusion This study's main findings are that BMI affect vitamin D response in healthy men. Quantitative supplementation adjustments may be warranted in obese men, for whom the dose may need to be doubled. This article is part of a special issue entitled '16th Vitamin D Workshop'.
KW - 25(OH)D
KW - Age
KW - BMI
KW - Men
KW - Season
KW - Sun-exposure
KW - Supplementation
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=84906790168&partnerID=8YFLogxK
U2 - 10.1016/j.jsbmb.2013.12.005
DO - 10.1016/j.jsbmb.2013.12.005
M3 - Review article
AN - SCOPUS:84906790168
SN - 0960-0760
VL - 144
SP - 163
EP - 166
JO - Journal of Steroid Biochemistry and Molecular Biology
JF - Journal of Steroid Biochemistry and Molecular Biology
IS - PART A
ER -