Pregnancy and multiple sclerosis: A 2-year experience

Raoul Orvieto, Reuwen Achiron, Zeev Rotstein, Shlomo Noy, Itai Bar-Hava, Anat Achiron

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Objective: To present our experience with management of parturients with multiple sclerosis and to examine the role of intravenous immunoglobulin (IVIg) in the prevention of postpartum exacerbations of the disease. Methods: Fifteen patients with multiple sclerosis with a relapsing-remitting course were followed during pregnancy and 6 months postpartum. To prevent postpartum exacerbations, 14 of the patients had received IVIg after delivery. Results: None of the patients who received postpartum IVIg relapsed during the 6 months after delivery. None of the observed obstetric complications nor the operative deliveries could be related to the coexistence of multiple sclerosis. Conclusion: Postpartum IVIg treatment is beneficial in preventing acute childbirth-associated exacerbations in patients with relapsing-remitting multiple sclerosis. Furthermore, this disease does not seem to increase obstetric complications. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Issue number2
StatePublished - 1 Feb 1999
Externally publishedYes


  • IVIg
  • Multiple sclerosis
  • Post-partum exacerbations

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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