Pregnancy complication and outcome in women with history of allergy to medicinal agents

Iris Ohel, Amalia Levy, Aya Zweig, Gershon Holcberg, Eyal Sheiner

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Problem: Pregnancy outcome in women with a previous history of drug allergy and the role of drug allergies in adverse pregnancy outcomes is unclear. Method of study: A retrospective cohort study comparing pregnancies of women with and without history of drug allergy was conducted. Data were collected from the computerized perinatal database. A multiple logistic regression model, with background elimination, was constructed to control for confounders. Results: Of 186,443 deliveries, 4.6% (n = 8647) occurred in patients with a history of drug allergy. The following conditions were significantly associated with a history of drug allergy: advanced maternal age, recurrent abortions, fertility treatments, hypertensive disorders, and diabetes mellitus. Using multivariate analysis, with background elimination, history of drug allergy was significantly associated with intrauterine growth restriction (OR = 1.52, CI = 1.3-0.8, P < 0.001) and with preterm delivery (OR = 1.26, CI = 1.14-1.38, P < 0.001). Conclusion: A history of drug allergy is an independent risk factor for intrauterine growth restriction and preterm delivery. Further prospective studies are needed to investigate the nature of this association.

Original languageEnglish
Pages (from-to)152-158
Number of pages7
JournalAmerican Journal of Reproductive Immunology
Issue number2
StatePublished - 1 Jan 2010


  • Allergy
  • Intrauterine growth restriction
  • Pregnancy outcome
  • Preterm labor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology


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