Pregnancy outcome of patients with pruritic urticarial papules and plaques of pregnancy

Iris Ohel, Amalia Levy, Tali Silberstein, Gershon Holcberg, Eyal Sheiner

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Objective. The study was designed to investigate obstetric risk factors and pregnancy outcome of patients with pruritic urticarial papules and plaques of pregnancy (PUPPP). Methods. A population-based study comparing all pregnancies of women with and without PUPPP was conducted. Deliveries occurred during the years 1988-2002 at the Soroka University Medical Center. A multivariable logistic regression model was constructed in order to find independent risk factors associated with PUPPP. Results. During a 15-year period, 159 197 deliveries took place. PUPPP complicated 42 (0.03%) of all pregnancies. Using a multivariable analysis, the following conditions were significantly associated with PUPPP: multiple pregnancies (odds ratio (OR) = 4.9, 95% confidence interval (CI) 1.7-14.1), hypertensive disorders (OR = 2.2, 95% CI 1.1-4.7), and induction of labor (OR = 7.6, 95% CI 4.0-14.5). Higher rates of 5-minute Apgar scores lower than 7 (OR = 8.0, 95% CI 4.4-14.9) and of cesarean deliveries (OR = 2.9, 95% CI 1.5-5.6) were noted in the PUPPP as compared to the comparison group. While investigating other perinatal outcome parameters such as oligohydramnios, intrauterine growth restriction, meconium-stained amniotic fluid and perinatal mortality, no significant differences were observed between the groups. Conclusion. Pruritic urticarial papules and plaques of pregnancy is a condition significantly associated with multiple pregnancies, hypertensive disorders, and induction of labor. Perinatal outcome is comparable to pregnancies without PUPPP.

Original languageEnglish
Pages (from-to)305-308
Number of pages4
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume19
Issue number5
DOIs
StatePublished - 1 May 2006
Externally publishedYes

Keywords

  • Low Apgar scores
  • Maternal obesity
  • Multiple pregnancies
  • Pregnancy outcome
  • Pruritic urticarial papules and plaques of pregnancy

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