Preliminary description of lesions in juvenile largemouth bass injected with largemouth bass virus

Dina Zilberg, John M. Grizzle, John A. Plumb

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Juvenile largemouth bass Micropterus salmoides were intraperitoneally injected with largemouth bass virus (LMBV), a member of the genus Ranavirus, family Iridoviridae. Moribund fish which had been injected with 106.2 tissue culture infectious doses, 50% endpoint (TCID50), were sampled 4 d after injection; other largemouth bass injected with this dose died between 3 and 5 d after injection. Fish injected with 102.8 TCID50 of LMBV were also examined after 4 d and had lesions similar to those of fish injected with the high dose. Clinical signs included darker pigmentation, inflammation and necrosis at the site of injection, distended abdomen, corkscrew swimming, and lateral recumbency. Internally, fish had focally pale livers, bright red spleens and reddened intestinal ceca. Histologically acute fibrinous peritonitis affected the surface of all organs in the peritoneal cavity, but deeper portions of organs appeared normal. There was also necrosis of the gastrointestinal mucosa. Except for the injection site, lesions were confined to the peritoneal cavity.

Original languageEnglish
Pages (from-to)143-146
Number of pages4
JournalDiseases of Aquatic Organisms
Issue number2
StatePublished - 14 Jan 2000
Externally publishedYes


  • Fish virus
  • Histopathology
  • Iridoviridae
  • Ranavirus

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Aquatic Science


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