Premedication with metoclopramide decreases the frequency of methohexital induced hiccup

Anatoli Stav, Natan Weksler, Michael Berman, Lusia Lemberg, Leonid Ribak, Anat Segal, Evgenia Machamid, Leon Ovadia, Ahud Sternberg

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Metoclopramide is one of many drugs that have been recommended for the treatment of intractable hiccup. Methohexital may produce hiccup during induction of general anesthesia. 211 women received methohexital for induction and maintenance of general anesthesia for short gynaecological procedures. All the patients were premedicated with fentanyl, diazepam and atropine. 109 patients were randomly selected to receive metoclopramide before induction of anesthesia; the remaining 102 patients served as a control group, and were anesthetized without metoclopramide premedication. The frequency of hiccup was compared between the two groups. 7 patients had hiccup in the metoclopramide premedicated group, as compared to 17 patients in the control group. This difference was statistically significant. We conclude that metoclopramide reduces the frequency of methohexital induced hiccup, and recommend that metoclopramide be routinely used for the premedication of methohexital injection. Stav A, Weksler N, Berman M: premedication with metcoclopramide decreases the frequency of methohexital induced hiccup. J Anesth 6: 17–20, 1992

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalJournal of Anesthesia
Issue number1
StatePublished - 1 Jan 1992
Externally publishedYes


  • Hiccup
  • Methohexital
  • Metoclopramide

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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