TY - JOUR
T1 - Premedication with Xylocaine spray does not lead to a false positive rapid urease test
AU - Sperber, A. D.
AU - Fich, A.
AU - Sztarkier, I.
AU - Zirkin, H. J.
AU - Krugliak, P.
AU - Odes, H. S.
AU - Hilzenrat, N.
AU - Gaspar, N.
AU - Zilberman, A.
PY - 1998/6/25
Y1 - 1998/6/25
N2 - Rapid urease tests are used for quick identification of Helicobacter pylori during upper gastrointestinal endoscopy. Rapid urease test solutions contain urea, which in the presence of H. pylori urease, generates ammonia, which changes the test medium color to indicate a positive result. Theoretically, Xylocaine spray (ASTRA, Sodertalje, Sweden), which has a basic pH value, could cause a similar positive reaction in the test medium. To determine whether patients premedicated with Xylocaine spray have a higher rate of false positive urease tests, we compared the results of a rapid urease test and histologic stains in 107 patients, 54 premedicated with Xylocaine spray and 53 premedicated with intravenous midazolam but not Xylocaine spray. There were no significant differences in test sensitivity, specificity, or predictive values between the study groups. We conclude that patients can be premedicated with Xylocaine spray without concern that the false positive rate of rapid urease tests will increase.
AB - Rapid urease tests are used for quick identification of Helicobacter pylori during upper gastrointestinal endoscopy. Rapid urease test solutions contain urea, which in the presence of H. pylori urease, generates ammonia, which changes the test medium color to indicate a positive result. Theoretically, Xylocaine spray (ASTRA, Sodertalje, Sweden), which has a basic pH value, could cause a similar positive reaction in the test medium. To determine whether patients premedicated with Xylocaine spray have a higher rate of false positive urease tests, we compared the results of a rapid urease test and histologic stains in 107 patients, 54 premedicated with Xylocaine spray and 53 premedicated with intravenous midazolam but not Xylocaine spray. There were no significant differences in test sensitivity, specificity, or predictive values between the study groups. We conclude that patients can be premedicated with Xylocaine spray without concern that the false positive rate of rapid urease tests will increase.
KW - Endoscopy
KW - False positive
KW - Rapid urease tests
UR - http://www.scopus.com/inward/record.url?scp=0031744896&partnerID=8YFLogxK
U2 - 10.1097/00004836-199806000-00010
DO - 10.1097/00004836-199806000-00010
M3 - Article
AN - SCOPUS:0031744896
VL - 26
SP - 267
EP - 268
JO - Journal of Clinical Gastroenterology
JF - Journal of Clinical Gastroenterology
SN - 0192-0790
IS - 4
ER -