Prenatal exposure to preeclampsia as a risk factor for long-term endocrine morbidity of the offspring

Sharon Davidesko, Kira Nahum Sacks, Michael Friger, Alon Haim, Eyal Sheiner

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objective: To analyze preeclampsia as a risk factor for pediatric endocrine disease. Study Design: A population-based cohort analysis comparing the risk of endocrine morbidity of children born between 1991-2014 to mothers with and without preeclampsia. Results: The study included 253,808 deliveries. Exposed offspring had significantly more endocrine hospitalizations (0.7% vs 0.4%; p < 0.001), specifically obesity (0.4% vs 0.2%, p < 0.001). While controlling for confounders, the exposed offspring had significantly more endocrine morbidity (OR 1.433 95% CI 1.115–1.841 p = 0.005). Conclusion: Preeclampsia is an independent risk factor for long-term endocrine disease of the offspring, specifically obesity.

Original languageEnglish
Pages (from-to)21-28
Number of pages8
JournalHypertension in Pregnancy
Volume40
Issue number1
DOIs
StatePublished - 1 Jan 2021

Keywords

  • Preeclampsia
  • endocrine
  • hypertension
  • pediatric
  • pregnancy

ASJC Scopus subject areas

  • Internal Medicine
  • Obstetrics and Gynecology

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