Prenatal exposure to preeclampsia as a risk factor for long-term endocrine morbidity of the offspring

Sharon Davidesko; Kira Nahum Sacks; Michael Friger; Alon Haim; Eyal Sheiner

doi:10.1080/10641955.2020.1854300

Prenatal exposure to preeclampsia as a risk factor for long-term endocrine morbidity of the offspring

Sharon Davidesko, Kira Nahum Sacks, Michael Friger, Alon Haim, Eyal Sheiner

Department of Epidemiology, Biostatistics and Community Health Sciences

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Objective: To analyze preeclampsia as a risk factor for pediatric endocrine disease. Study Design: A population-based cohort analysis comparing the risk of endocrine morbidity of children born between 1991-2014 to mothers with and without preeclampsia. Results: The study included 253,808 deliveries. Exposed offspring had significantly more endocrine hospitalizations (0.7% vs 0.4%; p < 0.001), specifically obesity (0.4% vs 0.2%, p < 0.001). While controlling for confounders, the exposed offspring had significantly more endocrine morbidity (OR 1.433 95% CI 1.115–1.841 p = 0.005). Conclusion: Preeclampsia is an independent risk factor for long-term endocrine disease of the offspring, specifically obesity.

Original language	English
Pages (from-to)	21-28
Number of pages	8
Journal	Hypertension in Pregnancy
Volume	40
Issue number	1
DOIs	https://doi.org/10.1080/10641955.2020.1854300
State	Published - 1 Jan 2021

Keywords

Preeclampsia
endocrine
hypertension
pediatric
pregnancy

ASJC Scopus subject areas

Internal Medicine
Obstetrics and Gynecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/10641955.2020.1854300

Cite this

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title = "Prenatal exposure to preeclampsia as a risk factor for long-term endocrine morbidity of the offspring",

abstract = "Objective: To analyze preeclampsia as a risk factor for pediatric endocrine disease. Study Design: A population-based cohort analysis comparing the risk of endocrine morbidity of children born between 1991-2014 to mothers with and without preeclampsia. Results: The study included 253,808 deliveries. Exposed offspring had significantly more endocrine hospitalizations (0.7% vs 0.4%; p < 0.001), specifically obesity (0.4% vs 0.2%, p < 0.001). While controlling for confounders, the exposed offspring had significantly more endocrine morbidity (OR 1.433 95% CI 1.115–1.841 p = 0.005). Conclusion: Preeclampsia is an independent risk factor for long-term endocrine disease of the offspring, specifically obesity.",

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AU - Sheiner, Eyal

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N2 - Objective: To analyze preeclampsia as a risk factor for pediatric endocrine disease. Study Design: A population-based cohort analysis comparing the risk of endocrine morbidity of children born between 1991-2014 to mothers with and without preeclampsia. Results: The study included 253,808 deliveries. Exposed offspring had significantly more endocrine hospitalizations (0.7% vs 0.4%; p < 0.001), specifically obesity (0.4% vs 0.2%, p < 0.001). While controlling for confounders, the exposed offspring had significantly more endocrine morbidity (OR 1.433 95% CI 1.115–1.841 p = 0.005). Conclusion: Preeclampsia is an independent risk factor for long-term endocrine disease of the offspring, specifically obesity.

AB - Objective: To analyze preeclampsia as a risk factor for pediatric endocrine disease. Study Design: A population-based cohort analysis comparing the risk of endocrine morbidity of children born between 1991-2014 to mothers with and without preeclampsia. Results: The study included 253,808 deliveries. Exposed offspring had significantly more endocrine hospitalizations (0.7% vs 0.4%; p < 0.001), specifically obesity (0.4% vs 0.2%, p < 0.001). While controlling for confounders, the exposed offspring had significantly more endocrine morbidity (OR 1.433 95% CI 1.115–1.841 p = 0.005). Conclusion: Preeclampsia is an independent risk factor for long-term endocrine disease of the offspring, specifically obesity.

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Prenatal exposure to preeclampsia as a risk factor for long-term endocrine morbidity of the offspring

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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