Prenatal particulate air pollution and neurodevelopment in urban children: Examining sensitive windows and sex-specific associations

Yueh Hsiu Mathilda Chiu, Hsiao Hsien Leon Hsu, Brent A. Coull, David C. Bellinger, Itai Kloog, Joel Schwartz, Robert O. Wright, Rosalind J. Wright

Research output: Contribution to journalArticlepeer-review

188 Scopus citations

Abstract

Background: Brain growth and structural organization occurs in stages beginning prenatally. Toxicants may impact neurodevelopment differently dependent upon exposure timing and fetal sex. Objectives: We implemented innovative methodology to identify sensitive windows for the associations between prenatal particulate matter with diameter≤2.5μm (PM2.5) and children's neurodevelopment. Methods: We assessed 267 full-term urban children's prenatal daily PM2.5 exposure using a validated satellite-based spatio-temporally resolved prediction model. Outcomes included IQ (WISC-IV), attention (omission errors [OEs], commission errors [CEs], hit reaction time [HRT], and HRT standard error [HRT-SE] on the Conners' CPT-II), and memory (general memory [GM] index and its components - verbal [VEM] and visual [VIM] memory, and attention-concentration [AC] indices on the WRAML-2) assessed at age 6.5±0.98years. To identify the role of exposure timing, we used distributed lag models to examine associations between weekly prenatal PM2.5 exposure and neurodevelopment. Sex-specific associations were also examined. Results: Mothers were primarily minorities (60% Hispanic, 25% black); 69% had ≤12years of education. Adjusting for maternal age, education, race, and smoking, we found associations between higher PM2.5 levels at 31-38weeks with lower IQ, at 20-26weeks gestation with increased OEs, at 32-36weeks with slower HRT, and at 22-40weeks with increased HRT-SE among boys, while significant associations were found in memory domains in girls (higher PM2.5 exposure at 18-26weeks with reduced VIM, at 12-20weeks with reduced GM). Conclusions: Increased PM2.5 exposure in specific prenatal windows may be associated with poorer function across memory and attention domains with variable associations based on sex. Refined determination of time window- and sex-specific associations may enhance insight into underlying mechanisms and identification of vulnerable subgroups.

Original languageEnglish
Pages (from-to)56-65
Number of pages10
JournalEnvironment international
Volume87
DOIs
StatePublished - 1 Feb 2016

Keywords

  • Air pollution
  • Neurodevelopment
  • Particulate matter
  • Prenatal exposure
  • Sensitive windows
  • Sex-specific associations

ASJC Scopus subject areas

  • General Environmental Science

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