Prenatal particulate matter exposure and mitochondrial dysfunction at the maternal-fetal interface: Effect modification by maternal lifetime trauma and child sex

Kelly J. Brunst, Marco Sanchez-Guerra, Yueh Hsiu Mathilda Chiu, Ander Wilson, Brent A. Coull, Itai Kloog, Joel Schwartz, Kasey J. Brennan, Michelle Bosquet Enlow, Robert O. Wright, Andrea A. Baccarelli, Rosalind J. Wright

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Background Prenatal ambient fine particulate matter (PM2.5) and maternal chronic psychosocial stress have independently been linked to changes in mithochondrial DNA copy number (mtDNAcn), a marker of mitochondrial response and dysfunction. Further, overlapping research shows sex-specific effects of PM2.5 and stress on developmental outcomes. Interactions among PM2.5, maternal stress, and child sex have not been examined in this context. Methods We examined associations among exposure to prenatal PM2.5, maternal lifetime traumatic stressors, and mtDNAcn at birth in a sociodemographically diverse pregnancy cohort (N = 167). Mothers' daily exposure to PM2.5 over gestation was estimated using a satellite-based spatio-temporally resolved prediction model. Lifetime exposure to traumatic stressors was ascertained using the Life Stressor Checklist-Revised; exposure was categorized as high vs. low based on a median split. Quantitative real-time polymerase chain reaction (qPCR) was used to determine mtDNAcn in placenta and cord blood leukocytes. Bayesian Distributed Lag Interaction regression models (BDLIMs) were used to statistically model and visualize the PM2.5 timing-dependent pattern of associations with mtDNAcn and explore effect modification by maternal lifetime trauma and child sex. Results Increased PM2.5 exposure across pregnancy was associated with decreased mtDNAcn in cord blood (cumulative effect estimate = − 0.78; 95%CI − 1.41, − 0.16). Higher maternal lifetime trauma was associated with reduced mtDNAcn in placenta (β = − 0.33; 95%CI − 0.63, − 0.02). Among women reporting low trauma, increased PM2.5 exposure late in pregnancy (30–38 weeks gestation) was significantly associated with decreased mtDNAcn in placenta; no significant association was found in the high trauma group. BDLIMs identified a significant 3-way interaction between PM2.5, maternal trauma, and child sex. Specifically, PM2.5 exposure between 25 and 40 weeks gestation was significantly associated with increased placental mtDNAcn among boys of mothers reporting high trauma. In contrast, PM2.5 exposure in this same window was significantly associated with decreased placental mtDNAcn among girls of mothers reporting low trauma. Similar 3-way interactive effects were observed in cord blood. Conclusions These results indicate that joint exposure to PM2.5 in late pregnancy and maternal lifetime trauma influence mtDNAcn at the maternal-fetal interface in a sex-specific manner. Additional studies will assist in understanding if the sex-specific patterns reflect distinct pathophysiological processes in addition to mitochondrial dysfunction.

Original languageEnglish
Pages (from-to)49-58
Number of pages10
JournalEnvironment international
Volume112
DOIs
StatePublished - 1 Mar 2018

Keywords

  • Air pollution
  • Bioenergetics
  • Mitochondria
  • Pregnancy
  • Psychosocial stress

ASJC Scopus subject areas

  • Environmental Science (all)

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