Prenatal particulate matter exposure and mitochondrial mutational load at the maternal-fetal interface: Effect modification by genetic ancestry

Kelly J. Brunst; Hsiao Hsien Leon Hsu; Li Zhang; Xiang Zhang; Kecia N. Carroll; Allan Just; Brent A. Coull; Itai Kloog; Robert O. Wright; Andrea A. Baccarelli; Rosalind J. Wright

doi:10.1016/j.mito.2021.11.003

Prenatal particulate matter exposure and mitochondrial mutational load at the maternal-fetal interface: Effect modification by genetic ancestry

Kelly J. Brunst, Hsiao Hsien Leon Hsu, Li Zhang, Xiang Zhang, Kecia N. Carroll, Allan Just, Brent A. Coull, Itai Kloog, Robert O. Wright, Andrea A. Baccarelli, Rosalind J. Wright

Department of Environmental, Geoinformatics and Urban Planning Sciences

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Prenatal ambient particulate matter (PM_2.5) exposure impacts infant development and alters placental mitochondrial DNA abundance. We investigated whether the timing of PM_2.5 exposure predicts placental mitochondrial mutational load using NextGen sequencing in 283 multi-ethnic mother-infant dyads. We observed increased PM_2.5 exposure, particularly during mid- to late-pregnancy and among genes coding for NADH dehydrogenase and subunits of ATP synthase, was associated with a greater amount of nonsynonymous mutations. The strongest associations were observed for participants of African ancestry. Further work is needed to tease out the role of mitochondrial genetics and its impact on offspring development and emerging disease disparities.

Original language	English
Pages (from-to)	102-110
Number of pages	9
Journal	Mitochondrion
Volume	62
DOIs	https://doi.org/10.1016/j.mito.2021.11.003
State	Published - 1 Jan 2022

Keywords

Air pollution
Bioenergetics
Mitochondria
Pregnancy

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.mito.2021.11.003

Cite this

Brunst, K. J., Hsu, H. H. L., Zhang, L., Zhang, X., Carroll, K. N., Just, A., Coull, B. A., Kloog, I., Wright, R. O., Baccarelli, A. A., & Wright, R. J. (2022). Prenatal particulate matter exposure and mitochondrial mutational load at the maternal-fetal interface: Effect modification by genetic ancestry. Mitochondrion, 62, 102-110. https://doi.org/10.1016/j.mito.2021.11.003

@article{7ef6edb440b2411a91a21796db733093,

title = "Prenatal particulate matter exposure and mitochondrial mutational load at the maternal-fetal interface: Effect modification by genetic ancestry",

abstract = "Prenatal ambient particulate matter (PM2.5) exposure impacts infant development and alters placental mitochondrial DNA abundance. We investigated whether the timing of PM2.5 exposure predicts placental mitochondrial mutational load using NextGen sequencing in 283 multi-ethnic mother-infant dyads. We observed increased PM2.5 exposure, particularly during mid- to late-pregnancy and among genes coding for NADH dehydrogenase and subunits of ATP synthase, was associated with a greater amount of nonsynonymous mutations. The strongest associations were observed for participants of African ancestry. Further work is needed to tease out the role of mitochondrial genetics and its impact on offspring development and emerging disease disparities.",

keywords = "Air pollution, Bioenergetics, Mitochondria, Pregnancy",

author = "Brunst, {Kelly J.} and Hsu, {Hsiao Hsien Leon} and Li Zhang and Xiang Zhang and Carroll, {Kecia N.} and Allan Just and Coull, {Brent A.} and Itai Kloog and Wright, {Robert O.} and Baccarelli, {Andrea A.} and Wright, {Rosalind J.}",

note = "Publisher Copyright: {\textcopyright} 2021",

year = "2022",

month = jan,

day = "1",

doi = "10.1016/j.mito.2021.11.003",

language = "English",

volume = "62",

pages = "102--110",

journal = "Mitochondrion",

issn = "1567-7249",

publisher = "Elsevier",

}

TY - JOUR

T1 - Prenatal particulate matter exposure and mitochondrial mutational load at the maternal-fetal interface

T2 - Effect modification by genetic ancestry

AU - Brunst, Kelly J.

AU - Hsu, Hsiao Hsien Leon

AU - Zhang, Li

AU - Zhang, Xiang

AU - Carroll, Kecia N.

AU - Just, Allan

AU - Coull, Brent A.

AU - Kloog, Itai

AU - Wright, Robert O.

AU - Baccarelli, Andrea A.

AU - Wright, Rosalind J.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Prenatal ambient particulate matter (PM2.5) exposure impacts infant development and alters placental mitochondrial DNA abundance. We investigated whether the timing of PM2.5 exposure predicts placental mitochondrial mutational load using NextGen sequencing in 283 multi-ethnic mother-infant dyads. We observed increased PM2.5 exposure, particularly during mid- to late-pregnancy and among genes coding for NADH dehydrogenase and subunits of ATP synthase, was associated with a greater amount of nonsynonymous mutations. The strongest associations were observed for participants of African ancestry. Further work is needed to tease out the role of mitochondrial genetics and its impact on offspring development and emerging disease disparities.

AB - Prenatal ambient particulate matter (PM2.5) exposure impacts infant development and alters placental mitochondrial DNA abundance. We investigated whether the timing of PM2.5 exposure predicts placental mitochondrial mutational load using NextGen sequencing in 283 multi-ethnic mother-infant dyads. We observed increased PM2.5 exposure, particularly during mid- to late-pregnancy and among genes coding for NADH dehydrogenase and subunits of ATP synthase, was associated with a greater amount of nonsynonymous mutations. The strongest associations were observed for participants of African ancestry. Further work is needed to tease out the role of mitochondrial genetics and its impact on offspring development and emerging disease disparities.

KW - Air pollution

KW - Bioenergetics

KW - Mitochondria

KW - Pregnancy

UR - http://www.scopus.com/inward/record.url?scp=85119350956&partnerID=8YFLogxK

U2 - 10.1016/j.mito.2021.11.003

DO - 10.1016/j.mito.2021.11.003

M3 - Article

C2 - 34785263

AN - SCOPUS:85119350956

SN - 1567-7249

VL - 62

SP - 102

EP - 110

JO - Mitochondrion

JF - Mitochondrion

ER -

Prenatal particulate matter exposure and mitochondrial mutational load at the maternal-fetal interface: Effect modification by genetic ancestry

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this