Prenatal particulate matter exposure and mitochondrial mutational load at the maternal-fetal interface: Effect modification by genetic ancestry

Kelly J. Brunst, Hsiao Hsien Leon Hsu, Li Zhang, Xiang Zhang, Kecia N. Carroll, Allan Just, Brent A. Coull, Itai Kloog, Robert O. Wright, Andrea A. Baccarelli, Rosalind J. Wright

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Prenatal ambient particulate matter (PM2.5) exposure impacts infant development and alters placental mitochondrial DNA abundance. We investigated whether the timing of PM2.5 exposure predicts placental mitochondrial mutational load using NextGen sequencing in 283 multi-ethnic mother-infant dyads. We observed increased PM2.5 exposure, particularly during mid- to late-pregnancy and among genes coding for NADH dehydrogenase and subunits of ATP synthase, was associated with a greater amount of nonsynonymous mutations. The strongest associations were observed for participants of African ancestry. Further work is needed to tease out the role of mitochondrial genetics and its impact on offspring development and emerging disease disparities.

Original languageEnglish
Pages (from-to)102-110
Number of pages9
JournalMitochondrion
Volume62
DOIs
StatePublished - 1 Jan 2022

Keywords

  • Air pollution
  • Bioenergetics
  • Mitochondria
  • Pregnancy

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

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