TY - JOUR
T1 - Prenatal PM2.5 exposure and neurodevelopment at 2 years of age in a birth cohort from Mexico city
AU - Hurtado-Díaz, Magali
AU - Riojas-Rodríguez, Horacio
AU - Rothenberg, Stephen J.
AU - Schnaas-Arrieta, Lourdes
AU - Kloog, Itai
AU - Just, Allan
AU - Hernández-Bonilla, David
AU - Wright, Robert O.
AU - Téllez-Rojo, Martha Ma
N1 - Publisher Copyright:
© 2021 Elsevier GmbH
PY - 2021/4/1
Y1 - 2021/4/1
N2 - Background: Recent studies have reported that air pollution exposure may have neurotoxic properties. Objective: To examine longitudinal associations between prenatal particles less than 2.5 μm in diameter (PM2.5) exposure and neurodevelopment during the first two years of children's life. Methods: Analysis was conducted in PROGRESS, a longitudinal birth cohort between 2007 and 2013 in Mexico City. We used satellite data to predict daily PM2.5 concentrations at high spatial resolution. Multivariate mixed-effect regression models were adjusted to examine cognitive, language and motor scores in children up to 24 months of age (n = 740) and each trimester-specific and whole pregnancy exposure to PM2.5. Results: Models adjusted by child sex, gestational age, birth weight, smoking and mother's IQ, showed that each increase of 1 μg/m3 of PM2.5 was associated with a decreased language function of −0.38 points (95% CI: −0.77, −0.01). PM2.5 exposure at third trimester of pregnancy contributed most to the observed association. Conclusion: Our findings suggest that language development up to 24 months of age may be particularly sensitive to PM2.5 exposure during pregnancy.
AB - Background: Recent studies have reported that air pollution exposure may have neurotoxic properties. Objective: To examine longitudinal associations between prenatal particles less than 2.5 μm in diameter (PM2.5) exposure and neurodevelopment during the first two years of children's life. Methods: Analysis was conducted in PROGRESS, a longitudinal birth cohort between 2007 and 2013 in Mexico City. We used satellite data to predict daily PM2.5 concentrations at high spatial resolution. Multivariate mixed-effect regression models were adjusted to examine cognitive, language and motor scores in children up to 24 months of age (n = 740) and each trimester-specific and whole pregnancy exposure to PM2.5. Results: Models adjusted by child sex, gestational age, birth weight, smoking and mother's IQ, showed that each increase of 1 μg/m3 of PM2.5 was associated with a decreased language function of −0.38 points (95% CI: −0.77, −0.01). PM2.5 exposure at third trimester of pregnancy contributed most to the observed association. Conclusion: Our findings suggest that language development up to 24 months of age may be particularly sensitive to PM2.5 exposure during pregnancy.
KW - Neurodevelopment
KW - PM
KW - Particulate matter
KW - Prenatal exposure
UR - http://www.scopus.com/inward/record.url?scp=85100731510&partnerID=8YFLogxK
U2 - 10.1016/j.ijheh.2021.113695
DO - 10.1016/j.ijheh.2021.113695
M3 - Article
C2 - 33582606
AN - SCOPUS:85100731510
SN - 1438-4639
VL - 233
JO - International Journal of Hygiene and Environmental Health
JF - International Journal of Hygiene and Environmental Health
M1 - 113695
ER -