Preoperative CA-125 level as a predictor of non optimal cytoreduction of advanced epithelial ovarian cancer

O. Gemer, S. Segal, A. Kopmar

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Background. Suboptimal cytoreduction of advanced ovarian cancer is related to initial tumor bulk which correlates with CA125 level. Methods. Retrospective record study of 40 patients with stage III ovarian cancer. The ability of a CA125 threshold level of 500 U/mL to predict suboptimal cytoreduction was determined. Results. Twenty-four (60%) of the patients were optimally cytoreduced. At the CA125 cut off level of 500 U/mL the sensitivity for predicting suboptimal debulking was 62% and specificity was 83%. Above a CA 125 level of 1500 U/mL none of the patients were optimally cytoreduced. Conclusions. More data are needed to determine the CA125 cut off level at which the standard approach of initial laparotomy and cytoreduction may be modified.

Original languageEnglish
Pages (from-to)583-585
Number of pages3
JournalActa Obstetricia et Gynecologica Scandinavica
Volume80
Issue number6
DOIs
StatePublished - 21 Jun 2001
Externally publishedYes

Keywords

  • CA 125
  • Cytoreduction
  • Ovarian cancer

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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