Preoperative irradiation and fluorouracil chemotherapy for locally advanced rectosigmoid carcinoma: Phase I-II study

Jerome C. Landry; Michael J. Koretz; William C. Wood; Sonny Bahri; Robin G. Smith; Michael Costa; George W. Daneker; Marty R. York; P. Ravi Sarma; Mike Lynn; Albert A. Ward; Patton H. McGinley; Lawrence W. Davis

doi:10.1148/radiology.188.2.8327689

Preoperative irradiation and fluorouracil chemotherapy for locally advanced rectosigmoid carcinoma: Phase I-II study

Jerome C. Landry, Michael J. Koretz, William C. Wood, Sonny Bahri, Robin G. Smith, Michael Costa, George W. Daneker, Marty R. York, P. Ravi Sarma, Mike Lynn, Albert A. Ward, Patton H. McGinley, Lawrence W. Davis

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

From June 1988 to July 1991, 20 patients with locally advanced rectal or rectosigmoid cancer were treated prospectively with a strategy of combining preoperative irradiation and fluorouracil chemotherapy before surgical resection. The preoperative radiation dose was 5,000 cGy, and fluorouracil chemotherapy was administered on the first and last 3 days of irradiation in an intravenous bolus dose of 500 mg/m². In a median follow-up of 25 months, the local regional failure rate was 10%. The 3-year actuarial overall survival and disease-free survival were 92% and 82%, respectively. Twenty percent of the surgical specimens showed no residual tumor, and only 10% showed positive lymph nodes. Significant leukopenia occurred in 10% of patients. Preoperative irradiation and fluorouracil chemotherapy increased surgical downstaging and improved local regional control. The overall toxicity was acceptable. The results of this particular multimodality approach are encouraging and warrant further investigation in phase III trials.

Original language	English
Pages (from-to)	423-426
Number of pages	4
Journal	Radiology
Volume	188
Issue number	2
DOIs	https://doi.org/10.1148/radiology.188.2.8327689
State	Published - 1 Jan 1993
Externally published	Yes

Keywords

Chemotherapy
Fluorouracil
Rectum, neoplasms, 756.321, 757.321
Therapeutic radiology, preoperative

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1148/radiology.188.2.8327689

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Landry, J. C., Koretz, M. J., Wood, W. C., Bahri, S., Smith, R. G., Costa, M., Daneker, G. W., York, M. R., Sarma, P. R., Lynn, M., Ward, A. A., McGinley, P. H., & Davis, L. W. (1993). Preoperative irradiation and fluorouracil chemotherapy for locally advanced rectosigmoid carcinoma: Phase I-II study. Radiology, 188(2), 423-426. https://doi.org/10.1148/radiology.188.2.8327689

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title = "Preoperative irradiation and fluorouracil chemotherapy for locally advanced rectosigmoid carcinoma: Phase I-II study",

abstract = "From June 1988 to July 1991, 20 patients with locally advanced rectal or rectosigmoid cancer were treated prospectively with a strategy of combining preoperative irradiation and fluorouracil chemotherapy before surgical resection. The preoperative radiation dose was 5,000 cGy, and fluorouracil chemotherapy was administered on the first and last 3 days of irradiation in an intravenous bolus dose of 500 mg/m2. In a median follow-up of 25 months, the local regional failure rate was 10%. The 3-year actuarial overall survival and disease-free survival were 92% and 82%, respectively. Twenty percent of the surgical specimens showed no residual tumor, and only 10% showed positive lymph nodes. Significant leukopenia occurred in 10% of patients. Preoperative irradiation and fluorouracil chemotherapy increased surgical downstaging and improved local regional control. The overall toxicity was acceptable. The results of this particular multimodality approach are encouraging and warrant further investigation in phase III trials.",

keywords = "Chemotherapy, Fluorouracil, Rectum, neoplasms, 756.321, 757.321, Therapeutic radiology, preoperative",

author = "Landry, {Jerome C.} and Koretz, {Michael J.} and Wood, {William C.} and Sonny Bahri and Smith, {Robin G.} and Michael Costa and Daneker, {George W.} and York, {Marty R.} and Sarma, {P. Ravi} and Mike Lynn and Ward, {Albert A.} and McGinley, {Patton H.} and Davis, {Lawrence W.}",

year = "1993",

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doi = "10.1148/radiology.188.2.8327689",

language = "English",

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T1 - Preoperative irradiation and fluorouracil chemotherapy for locally advanced rectosigmoid carcinoma

T2 - Phase I-II study

AU - Landry, Jerome C.

AU - Koretz, Michael J.

AU - Wood, William C.

AU - Bahri, Sonny

AU - Smith, Robin G.

AU - Costa, Michael

AU - Daneker, George W.

AU - York, Marty R.

AU - Sarma, P. Ravi

AU - Lynn, Mike

AU - Ward, Albert A.

AU - McGinley, Patton H.

AU - Davis, Lawrence W.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - From June 1988 to July 1991, 20 patients with locally advanced rectal or rectosigmoid cancer were treated prospectively with a strategy of combining preoperative irradiation and fluorouracil chemotherapy before surgical resection. The preoperative radiation dose was 5,000 cGy, and fluorouracil chemotherapy was administered on the first and last 3 days of irradiation in an intravenous bolus dose of 500 mg/m2. In a median follow-up of 25 months, the local regional failure rate was 10%. The 3-year actuarial overall survival and disease-free survival were 92% and 82%, respectively. Twenty percent of the surgical specimens showed no residual tumor, and only 10% showed positive lymph nodes. Significant leukopenia occurred in 10% of patients. Preoperative irradiation and fluorouracil chemotherapy increased surgical downstaging and improved local regional control. The overall toxicity was acceptable. The results of this particular multimodality approach are encouraging and warrant further investigation in phase III trials.

AB - From June 1988 to July 1991, 20 patients with locally advanced rectal or rectosigmoid cancer were treated prospectively with a strategy of combining preoperative irradiation and fluorouracil chemotherapy before surgical resection. The preoperative radiation dose was 5,000 cGy, and fluorouracil chemotherapy was administered on the first and last 3 days of irradiation in an intravenous bolus dose of 500 mg/m2. In a median follow-up of 25 months, the local regional failure rate was 10%. The 3-year actuarial overall survival and disease-free survival were 92% and 82%, respectively. Twenty percent of the surgical specimens showed no residual tumor, and only 10% showed positive lymph nodes. Significant leukopenia occurred in 10% of patients. Preoperative irradiation and fluorouracil chemotherapy increased surgical downstaging and improved local regional control. The overall toxicity was acceptable. The results of this particular multimodality approach are encouraging and warrant further investigation in phase III trials.

KW - Chemotherapy

KW - Fluorouracil

KW - Rectum, neoplasms, 756.321, 757.321

KW - Therapeutic radiology, preoperative

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VL - 188

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JO - Radiology

JF - Radiology

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ER -

Preoperative irradiation and fluorouracil chemotherapy for locally advanced rectosigmoid carcinoma: Phase I-II study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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