Preparation and characterization of bioadhesive grafted starch copolymers as platforms for controlled drug delivery

Shimona Geresh, Ygal Gilboa, Julia Peisahov-Korol, Garik Gdalevsky, Jody Voorspoels, J. P. Remon, Joseph Kost

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

60Co-gamma-radiation and ceric ammonium nitrate (CAN) redox-induced graft polymerization of acrylic monomers (acrylonitrile, acrylic acid, and methyl acrylate) to starch was performed to produce drug-delivery systems. The grafted starches obtained mainly by redox-induced polymerization were characterized by chemical and physicochemical methods, and the nature and size of the polyacrylic moiety grafted to the starch were determined. Although the choice of grafting method depended in part on the particular monomer, only copolymers obtained by gamma radiation proved to be satisfactory drug delivery systems. Changes of parameters in the gamma radiation-induced polymerization, such as radiation times and changes in the amount of starch and/or acrylic monomers, were tested in terms of the release rate of model drug compounds.

Original languageEnglish
Pages (from-to)1157-1162
Number of pages6
JournalJournal of Applied Polymer Science
Volume86
Issue number5
DOIs
StatePublished - 31 Oct 2002

Keywords

  • Biocompatibility
  • Drug delivery systems
  • Gamma-ray initiation
  • Graft copolymers
  • Starch

ASJC Scopus subject areas

  • Chemistry (all)
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Materials Chemistry

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