Preparation and chiral separation of a novel immobilized cellulose-based chiral stationary phase in high-performance liquid chromatography

Gui Ming Peng; Su Qin Wu; Zhi Li Fang; Wei Guang Zhang; Zhen Bin Zhang; Jun Fan; Sheng Run Zheng; Shang Sen Wu; Siu Choon Ng

doi:10.1093/chromsci/bms047

Preparation and chiral separation of a novel immobilized cellulose-based chiral stationary phase in high-performance liquid chromatography

Gui Ming Peng, Su Qin Wu, Zhi Li Fang, Wei Guang Zhang, Zhen Bin Zhang, Jun Fan, Sheng Run Zheng, Shang Sen Wu, Siu Choon Ng

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The chiral selector 6-azido-2, 3-di(p-chlorophenylcarbamoylated) cellulose was synthesized and further chemically immobilized onto 5-mm amino functionalized spherical porous silica gel. It was used as chiral stationary phase in high-performance liquid chromatography. Thirty racemates were successfully separated into enantiomers in either normal phase mode or reversed-phase mode. Good reproducibility and stability of the chiral stationary phase have been demonstrated.

Original language	English
Pages (from-to)	516-522
Number of pages	7
Journal	Journal of Chromatographic Science
Volume	50
Issue number	6
DOIs	https://doi.org/10.1093/chromsci/bms047
State	Published - 1 Jul 2012
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry

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title = "Preparation and chiral separation of a novel immobilized cellulose-based chiral stationary phase in high-performance liquid chromatography",

abstract = "The chiral selector 6-azido-2, 3-di(p-chlorophenylcarbamoylated) cellulose was synthesized and further chemically immobilized onto 5-mm amino functionalized spherical porous silica gel. It was used as chiral stationary phase in high-performance liquid chromatography. Thirty racemates were successfully separated into enantiomers in either normal phase mode or reversed-phase mode. Good reproducibility and stability of the chiral stationary phase have been demonstrated.",

author = "Peng, {Gui Ming} and Wu, {Su Qin} and Fang, {Zhi Li} and Zhang, {Wei Guang} and Zhang, {Zhen Bin} and Jun Fan and Zheng, {Sheng Run} and Wu, {Shang Sen} and Ng, {Siu Choon}",

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T1 - Preparation and chiral separation of a novel immobilized cellulose-based chiral stationary phase in high-performance liquid chromatography

AU - Peng, Gui Ming

AU - Wu, Su Qin

AU - Fang, Zhi Li

AU - Zhang, Wei Guang

AU - Zhang, Zhen Bin

AU - Fan, Jun

AU - Zheng, Sheng Run

AU - Wu, Shang Sen

AU - Ng, Siu Choon

PY - 2012/7/1

Y1 - 2012/7/1

N2 - The chiral selector 6-azido-2, 3-di(p-chlorophenylcarbamoylated) cellulose was synthesized and further chemically immobilized onto 5-mm amino functionalized spherical porous silica gel. It was used as chiral stationary phase in high-performance liquid chromatography. Thirty racemates were successfully separated into enantiomers in either normal phase mode or reversed-phase mode. Good reproducibility and stability of the chiral stationary phase have been demonstrated.

AB - The chiral selector 6-azido-2, 3-di(p-chlorophenylcarbamoylated) cellulose was synthesized and further chemically immobilized onto 5-mm amino functionalized spherical porous silica gel. It was used as chiral stationary phase in high-performance liquid chromatography. Thirty racemates were successfully separated into enantiomers in either normal phase mode or reversed-phase mode. Good reproducibility and stability of the chiral stationary phase have been demonstrated.

UR - http://www.scopus.com/inward/record.url?scp=84865581805&partnerID=8YFLogxK

U2 - 10.1093/chromsci/bms047

DO - 10.1093/chromsci/bms047

M3 - Article

C2 - 22523189

AN - SCOPUS:84865581805

SN - 0021-9665

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EP - 522

JO - Journal of Chromatographic Science

JF - Journal of Chromatographic Science

IS - 6

ER -

Preparation and chiral separation of a novel immobilized cellulose-based chiral stationary phase in high-performance liquid chromatography

Abstract

ASJC Scopus subject areas

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