Preparation and chiral separation of a novel immobilized cellulose-based chiral stationary phase in high-performance liquid chromatography

Gui Ming Peng; Su Qin Wu; Zhi Li Fang; Wei Guang Zhang; Zhen Bin Zhang; Jun Fan; Sheng Run Zheng; Shang Sen Wu; Siu Choon Ng

doi:10.1093/chromsci/bms047

Preparation and chiral separation of a novel immobilized cellulose-based chiral stationary phase in high-performance liquid chromatography

Gui Ming Peng
, Su Qin Wu
, Zhi Li Fang
, Wei Guang Zhang
, Zhen Bin Zhang
, Jun Fan
, Sheng Run Zheng
, Shang Sen Wu
, Siu Choon Ng

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The chiral selector 6-azido-2, 3-di(p-chlorophenylcarbamoylated) cellulose was synthesized and further chemically immobilized onto 5-mm amino functionalized spherical porous silica gel. It was used as chiral stationary phase in high-performance liquid chromatography. Thirty racemates were successfully separated into enantiomers in either normal phase mode or reversed-phase mode. Good reproducibility and stability of the chiral stationary phase have been demonstrated.

Original language	English
Pages (from-to)	516-522
Number of pages	7
Journal	Journal of Chromatographic Science
Volume	50
Issue number	6
DOIs	https://doi.org/10.1093/chromsci/bms047
State	Published - 1 Jul 2012
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry

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10.1093/chromsci/bms047

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title = "Preparation and chiral separation of a novel immobilized cellulose-based chiral stationary phase in high-performance liquid chromatography",

abstract = "The chiral selector 6-azido-2, 3-di(p-chlorophenylcarbamoylated) cellulose was synthesized and further chemically immobilized onto 5-mm amino functionalized spherical porous silica gel. It was used as chiral stationary phase in high-performance liquid chromatography. Thirty racemates were successfully separated into enantiomers in either normal phase mode or reversed-phase mode. Good reproducibility and stability of the chiral stationary phase have been demonstrated.",

author = "Peng, \{Gui Ming\} and Wu, \{Su Qin\} and Fang, \{Zhi Li\} and Zhang, \{Wei Guang\} and Zhang, \{Zhen Bin\} and Jun Fan and Zheng, \{Sheng Run\} and Wu, \{Shang Sen\} and Ng, \{Siu Choon\}",

year = "2012",

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doi = "10.1093/chromsci/bms047",

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journal = "Journal of Chromatographic Science",

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publisher = "Oxford University Press",

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TY - JOUR

T1 - Preparation and chiral separation of a novel immobilized cellulose-based chiral stationary phase in high-performance liquid chromatography

AU - Peng, Gui Ming

AU - Wu, Su Qin

AU - Fang, Zhi Li

AU - Zhang, Wei Guang

AU - Zhang, Zhen Bin

AU - Fan, Jun

AU - Zheng, Sheng Run

AU - Wu, Shang Sen

AU - Ng, Siu Choon

PY - 2012/7/1

Y1 - 2012/7/1

N2 - The chiral selector 6-azido-2, 3-di(p-chlorophenylcarbamoylated) cellulose was synthesized and further chemically immobilized onto 5-mm amino functionalized spherical porous silica gel. It was used as chiral stationary phase in high-performance liquid chromatography. Thirty racemates were successfully separated into enantiomers in either normal phase mode or reversed-phase mode. Good reproducibility and stability of the chiral stationary phase have been demonstrated.

AB - The chiral selector 6-azido-2, 3-di(p-chlorophenylcarbamoylated) cellulose was synthesized and further chemically immobilized onto 5-mm amino functionalized spherical porous silica gel. It was used as chiral stationary phase in high-performance liquid chromatography. Thirty racemates were successfully separated into enantiomers in either normal phase mode or reversed-phase mode. Good reproducibility and stability of the chiral stationary phase have been demonstrated.

UR - https://www.scopus.com/pages/publications/84865581805

U2 - 10.1093/chromsci/bms047

DO - 10.1093/chromsci/bms047

M3 - Article

C2 - 22523189

AN - SCOPUS:84865581805

SN - 0021-9665

VL - 50

SP - 516

EP - 522

JO - Journal of Chromatographic Science

JF - Journal of Chromatographic Science

IS - 6

ER -

Preparation and chiral separation of a novel immobilized cellulose-based chiral stationary phase in high-performance liquid chromatography

Abstract

ASJC Scopus subject areas

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