Pretreatment CA 15-3 levels do not predict disease-free survival in patients with advanced epithelial ovarian cancer

Ofer Gemer, Natalia Oustinov, Michael Gdalevich, Serge Dubnik, Roni Levy, Adela Yachnin, Ofer Lavie, Noa Ben Baruch, Alon Ben Arie

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Aims. To evaluate the role of pretreatment CA 15-3 levels as a predictor of disease-free survival in patients with advanced epithelial ovarian cancer. Methods. A cohort of 65 patients with FIGO stage III or IV epithelial ovarian cancer was evaluated. Patients were treated either with primary cytoreductive surgery followed by adjuvant platinum-based chemotherapy or with neoadjuvant chemotherapy with interval debulking surgery. All patients had pretreatment CA 15-3 and CA 125 tumor marker determinations. The patients were divided into a group with elevated CA 15-3 and a group with normal levels. The two groups were compared with regard to clinical and survival measures. Results. The patients' median age was 65 years (range, 37-90); 34 (52%) were at stage III and 31 (48%) at stage IV. CA 15-3 was elevated (>30 units/mL) in 44 (68%) patients, with a median level of 39 units (range, 4-2282). CA 125 was elevated (>35 units/mL) in 61 (94%) patients, with a median level of 947 units (range, 4-30,642). CA 125 and CA 15-3 levels were not correlated (r = 0.015, P = 0.332). The median follow-up was 22 months (range, 3-120 months). Fifty-three (81%) patients had disease recurrence and 43 (66%) died. Survival analysis showed that patients with elevated and normal CA 15-3 levels had similar recurrence-free survival (P = 0.78) and overall survival (P = 0.55). Conclusions. Although elevated in the majority of patients with advanced epithelial ovarian cancer, CA 15-3 levels are not predictive of survival.

Original languageEnglish
Pages (from-to)257-260
Number of pages4
JournalTumori
Volume99
Issue number2
DOIs
StatePublished - 1 Jan 2013

Keywords

  • CA 15-3
  • Ovarian cancer
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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