Prevalence of antiphospholipid and antioxidized low-density lipoprotein antibodies in rheumatoid arthritis

Yaniv Sherer, Roberto Gerli, Gaetano Vaudo, Giuseppe Schillaci, Boris Gilburd, Andrea Giordano, Elena Bartoloni Bocci, Rosita Allegrucci, Simona Marchesi, Elmo Mannarino, Yehuda Shoenfeld

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Antiphospholipid antibodies characterize the antiphospholipid syndrome (APS), but they can also be found in various autoimmune, infectious, and malignant conditions. This study's objectives were to detect the prevalence of antiphospholipid and antioxidized low-density lipoproiein (anti-oxLDL) antibodies among patients with rheumatoid arthritis (RA) who did not have clinical manifestations of APS. Using a standard enzyme-linked immunosorbent assay (ELISA), we evaluated the levels of immunoglobulin G (IgG) and IgM anticardiolipin, IgG, and IgM anti-beta-2-glycoprotein-I (anti- β2GPI), and anti-oxLDL autoantibodies in 82 patients with RA. The cutoff levels for detecting these autoantibodies were 15 IgG phospholipid units (GPL), 15 IgM phospholipid units (MPL), and 25 ELISA units (EU)/mL, respectively. Elevated levels of IgG anticardiolipin antibodies were detected in 17 of 82 (21%) RA patients, including 10 with low levels of IgG anticardiolipin and 7 with medium to high levels of anticardiolipin autoantibodies. IgM anticardiolipin was found in only 1 (1%) patient, and both IgG and IgM anti-β2GPI were found in 3 (4%) patients with RA. Elevated levels of anti-oxLDL antibodies were found in 8 (10%) patients, 4 of whom also had elevated levels of IgG anticardiolipin. We conclude that IgG anticardiolipin autoantibodies can be found in about one-fifth of RA patients who do not have clinical manifestations of APS. Whether the presence of anticardiolipin signifies increased risk for thrombosis and atherosclerosis in these patients should be studied further.

Original languageEnglish
Pages (from-to)299-303
Number of pages5
JournalAnnals of the New York Academy of Sciences
Volume1051
DOIs
StatePublished - 1 Jan 2005
Externally publishedYes

Keywords

  • Anti-beta-2 glycoprotein I
  • Anticardiolipin thrombosis
  • Antiphospholipid antibody
  • Antiphospholipid syndrome
  • Atherosclerosis
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Neuroscience (all)
  • Biochemistry, Genetics and Molecular Biology (all)
  • History and Philosophy of Science

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