Abstract
Background: The association between antiphospholipid antibodies (aPL) and multiple sclerosis (MS) has been suggested previously, but prior studies provided contradicting findings. Objectives: To characterize the expression profile of eight classic and non-classic aPL in patients diagnosed with MS. Methods: Using the BioPlex™ 2200 immunoassay, we measured the levels of serum immunoglobulin (Ig)M and IgG isotypes of three classic aPL and five non-classic aPL in 98 subjects with MS and 237 healthy controls. Results: Three non-classic aPL were significantly more prevalent among MS patients in comparison to the control group. These antibodies included IgM and IgG against phosphatidylserine- β2GPI (PS-B2), IgG prothrombin complex (PT-PT) and IgM prothrombin (PT). The positive results according to Bonferroni correction are PS-B2 IgG and PT-PT IgG. The remaining aPL profiles did not differ significantly between the two groups. Conclusions: An association between certain non-classic aPL and MS has been established. The specific role of these autoantibodies in the pathogenesis of the condition remains uncertain.
| Original language | English |
|---|---|
| Pages (from-to) | 559-562 |
| Number of pages | 4 |
| Journal | Israel Medical Association Journal |
| Volume | 17 |
| Issue number | 9 |
| State | Published - 1 Sep 2015 |
Keywords
- Antiphospholipid syndrome (APS)
- Autoantibodies
- Autoimmunity
- Beta 2-glycoprotein 1 (β2GPI)
- Cardiolipin
- Immunoglobulin (Ig)
- Multiple sclerosis (MS)
ASJC Scopus subject areas
- General Medicine