Preventing sleep on the first resting phase following a traumatic event attenuates anxiety-related responses

Shlomi Cohen, Zeev Kaplan, Joseph Zohar, Hagit Cohen

    Research output: Contribution to journalArticlepeer-review

    23 Scopus citations

    Abstract

    Sleep deprivation (SD) in the early aftermath of stress exposure at the onset of the inactive (resting)-phase, has been shown to ameliorate stress-related sequelae. We examined whether this effect is affected by the temporal proximity between SD and the stressful event or whether it was related to the prevention of sleep in the first resting phase following the exposure. Rats were exposed to stress at the onset of their active phase. Then, they were prevented from sleeping immediately thereafter [forced wakefulness (FW)], or during the first resting phase (SD). The behavior in the elevated plus-maze and acoustic startle response paradigms were assessed seven days post-exposure for retrospective classification into behavioral response groups. We found that resting phase SD (with or without FW) decreased PTSD-like phenotype, whereas immediate FW had no significant effect. The long-term anxiolytic effects of SD appear to stem from a diurnal cycle-dependent mechanism, such that preventing sleep during the first natural resting phase following the traumatic exposure is beneficial in preventing the traumatic sequelae.

    Original languageEnglish
    Pages (from-to)450-456
    Number of pages7
    JournalBehavioural Brain Research
    Volume320
    DOIs
    StatePublished - 1 Mar 2017

    Keywords

    • Animal model
    • Forced wakefulness
    • Memory consolidation
    • Posttraumatic stress disorder
    • Sleep deprivation

    ASJC Scopus subject areas

    • Behavioral Neuroscience

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