Primary refractory and relapsed classical hodgkin lymphoma - significance of differential CD15 expression in hodgkin-reed-sternberg cells

Daniel Benharroch, Shai Pilosof, Jacob Gopas, Itai Levi

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We recognized a few possible complications of classical Hodgkin lymphoma therapy in a cohort of 209 patients: 8 developed a primary refractory disease (primary progression), 36 showed an early relapse and 21 showed a late relapse. Sialyl-CD15 expression in Hodg-kin-Reed-Sternberg cells was significantly more positive in primary refractory Hodgkin lymphoma, which confirms our previously published findings. Bcl-2 showed a significantly lower level of expression in primary refractory disease than in the other follow-up groups. This is in contrast with a previous finding of Bcl-2, associated with a poor prognosis in primary refractory illness. Another category of variables, old age and advanced stages, was significantly different in the various complications but this finding is probably to be expected. We could not demonstrate a difference between the sequels and the control group with regard to several clinical and immunohistochemical markers. Sialyl-CD15 and Bcl-2 expression, in contrast, were confirmed as prognostic factors, mainly of tumor progression into primary refractory disease.

Original languageEnglish
Pages (from-to)322-327
Number of pages6
JournalJournal of Cancer
Volume3
Issue number1
DOIs
StatePublished - 14 Sep 2012

Keywords

  • Bcl-2
  • CD15
  • Classical Hodgkin lymphoma
  • Primary refractory
  • Relapse

ASJC Scopus subject areas

  • Oncology

Fingerprint

Dive into the research topics of 'Primary refractory and relapsed classical hodgkin lymphoma - significance of differential CD15 expression in hodgkin-reed-sternberg cells'. Together they form a unique fingerprint.

Cite this