Primary vs. secondary recurrent pregnancy loss - Epidemiological characteristics, etiology, and next pregnancy outcome

Efrat Shapira, Ronit Ratzon, Ilana Shoham-Vardi, Ruslan Serjienko, Moshe Mazor, Asher Bashiri

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Objective: To compare epidemiological and obstetric characteristics, etiology and next pregnancy outcomes of women with primary vs. secondary recurrent pregnancy loss (RPL). Study design: A retrospective cohort study, including 420 patients with two or more consecutive pregnancy losses followed by a subsequent (index) pregnancy, of whom 162 were primary RPL women and 258 were secondary RPL women. All patients were evaluated and treated in the RPL clinic at the Soroka University Medical Center. Results: Live birth rate in the index pregnancy was not statistically different between primary and secondary RPL women (75.9 and 70.9%, respectively). The only significant difference in the etiology evaluation was in abnormal prolactin levels (14.1% of the primary and 1.4% of the secondary RPL group). Women with primary RPL had, at the index pregnancy, significantly higher rates of preterm delivery, fetal growth restriction, and gestational diabetes mellitus. In a multivariable logistic regression analysis, primary RPL adjusted for maternal age and gravidity, was an independent risk factor for preterm delivery compared with secondary RPL [adjusted OR 2.62, CI (95%) 1.30-5.26]. Conclusions: The prognosis of the two groups was similar regarding live birth rate at the index pregnancy; however, women with primary RPL were more prone to adverse obstetric and neonatal outcomes.

Original languageEnglish
Pages (from-to)389-396
Number of pages8
JournalJournal of Perinatal Medicine
Issue number4
StatePublished - 1 Jun 2012
Externally publishedYes


  • Index pregnancy
  • Obstetric complications
  • Pregnancy outcome
  • Preterm delivery
  • Primary and secondary recurrent pregnancy loss

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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