Abstract
The burden of cardiovascular pathologies, such as heart failure after myocardial infarction or due to congenital heart defects, is still very high. Existing clinical therapies for these life-threatening conditions cannot regenerate and restore tissue function and provide mainly palliative treatment. This critical drawback has fueled the development of novel technologies aimed to repair or replace damaged heart tissue and correct heart defects. Such strategies, broadly termed “cardiovascular tissue engineering,” are a direct result of collaboration between researchers from various fields, such as material science, engineering, cardiovascular biology, and medicine. This chapter offers an overview of such multidisciplinary strategies, emphasizing the various concepts and major applications. The chapter could be of interest not only from an educational perspective, but also for researchers and medical professionals, offering a fresh view on novel and powerful treatment options based on tissue engineering and regeneration.
| Original language | English |
|---|---|
| Title of host publication | Tissue Engineering, Third Edition |
| Publisher | Elsevier |
| Pages | 629-660 |
| Number of pages | 32 |
| ISBN (Electronic) | 9780128244593 |
| ISBN (Print) | 9780323851343 |
| DOIs | |
| State | Published - 1 Jan 2022 |
Keywords
- Biomaterials
- Blood vessels
- Cardiovascular tissue engineering
- Myocardial infarction
- Myocardial regeneration
- Vascular grafts
ASJC Scopus subject areas
- General Agricultural and Biological Sciences
- General Biochemistry, Genetics and Molecular Biology
- General Medicine