Principles of Cardiovascular Tissue Engineering

Emil Ruvinov, Yulia Shandalov, Shulamit Levenberg, Smadar Cohen

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

The burden of cardiovascular pathologies, such as heart failure and vascular diseases, is still very high. The clinical therapies for these life-threatening conditions are unable to regenerate and restore tissue function, providing mainly palliative treatment. This critical drawback has fueled the development of novel technologies aimed to repair or replace damaged heart tissue or non-functioning vasculature. Such strategies, broadly termed 'cardiovascular tissue engineering', are a direct result of collaboration between researchers from various fields, such as material science, engineering, cardiovascular biology, and medicine. This chapter offers an overview of such multidisciplinary strategies, emphasizing the various concepts and major applications. The chapter could be of interest not only from an educational perspective, but also for researchers and medical professionals, offering a fresh view on novel and powerful treatment options based on tissue engineering and regeneration.

Original languageEnglish
Title of host publicationTissue Engineering
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages627-683
Number of pages57
ISBN (Print)9780124201453
DOIs
StatePublished - 10 Dec 2014

Keywords

  • Biomaterials
  • Bioreactors
  • Blood vessels
  • Cardiomyocytes
  • Cardiovascular tissue engineering
  • Heart failure
  • Myocardial infarction
  • Myocardial regeneration
  • Vascular grafts
  • Vascularization

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