PrLZ, a Novel Prostate-Specific and Androgen-Responsive Gene of the TPD52 Family, Amplified in Chromosome 8q21.1 and Overexpressed in Human Prostate Cancer

Ruoxiang Wang, Jianchun Xu, Outi Saramäki, Tapio Visakorpi, William M. Sutherland, Jianguang Zhou, Buer Sen, So Dug Lim, Nicola Mabjeesh, Mahul Amin, Jin Tang Dong, John A. Petros, Peter S. Nelson, Fray F. Marshall, Haiyen E. Zhau, Leland W.K. Chung

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Abstract

We report a previously unrecognized prostate-specific protein, PrLZ (prostate leucine zipper), a new member of the Tumor Protein D52 (TPD52) family. The gene for PrLZ was localized at chromosome 8q21.1, a locus most frequently amplified in human prostate cancer. Multiple tissue analyses demonstrated PrLZ predominantly in the prostate gland. Although its expression was enhanced by androgens in androgen receptor-expressing cells, PrLZ was detected in all of the human prostate cancer cell lines, regardless of androgen receptor status. Monoclonal anti-PrLZ antibodies were produced and intense immunohistochemical staining of PrLZ was observed in prostate epithelial cells in intraepithelial neoplasia and prostate cancer, whereas lower-level staining was detected in normal and benign epithelial components of the prostate gland. As the only prostate-specific gene identified in the most frequently amplified genomic region in prostate cancer, PrLZ may be the link between chromosome 8q amplification and malignant transformation of the prostate epithelia.

Original languageEnglish
Pages (from-to)1589-1594
Number of pages6
JournalCancer Research
Volume64
Issue number5
DOIs
StatePublished - 1 Mar 2004
Externally publishedYes

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