Production of dynamic lipid bilayers using the reversible thiol-thioester exchange reaction

Danielle Konetski; Sudheendran Mavila; Chen Wang; Brady Worrell; Christopher N. Bowman

doi:10.1039/c8cc03471k

Production of dynamic lipid bilayers using the reversible thiol-thioester exchange reaction

Danielle Konetski, Sudheendran Mavila, Chen Wang, Brady Worrell, Christopher N. Bowman

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Thiol lysolipids undergo thiol-thioester exchange with two phenyl thioester-functionalized tails to produce phospholipid structures that assemble into liposomes with differences in exchange rates, temperature sensitivity, permeability, and continued exchange behavior. This in situ formation reaction imparts dynamic characteristics into the membrane for downstream liposome functionalization and mimics native membrane remodeling.

Original language	English
Pages (from-to)	8108-8111
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	58
DOIs	https://doi.org/10.1039/c8cc03471k
State	Published - 1 Jan 2018
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Production of dynamic lipid bilayers using the reversible thiol-thioester exchange reaction",

abstract = "Thiol lysolipids undergo thiol-thioester exchange with two phenyl thioester-functionalized tails to produce phospholipid structures that assemble into liposomes with differences in exchange rates, temperature sensitivity, permeability, and continued exchange behavior. This in situ formation reaction imparts dynamic characteristics into the membrane for downstream liposome functionalization and mimics native membrane remodeling.",

author = "Danielle Konetski and Sudheendran Mavila and Chen Wang and Brady Worrell and Bowman, {Christopher N.}",

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AU - Konetski, Danielle

AU - Mavila, Sudheendran

AU - Wang, Chen

AU - Worrell, Brady

AU - Bowman, Christopher N.

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Thiol lysolipids undergo thiol-thioester exchange with two phenyl thioester-functionalized tails to produce phospholipid structures that assemble into liposomes with differences in exchange rates, temperature sensitivity, permeability, and continued exchange behavior. This in situ formation reaction imparts dynamic characteristics into the membrane for downstream liposome functionalization and mimics native membrane remodeling.

AB - Thiol lysolipids undergo thiol-thioester exchange with two phenyl thioester-functionalized tails to produce phospholipid structures that assemble into liposomes with differences in exchange rates, temperature sensitivity, permeability, and continued exchange behavior. This in situ formation reaction imparts dynamic characteristics into the membrane for downstream liposome functionalization and mimics native membrane remodeling.

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U2 - 10.1039/c8cc03471k

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EP - 8111

JO - Chemical Communications

JF - Chemical Communications

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ER -

Production of dynamic lipid bilayers using the reversible thiol-thioester exchange reaction

Abstract

ASJC Scopus subject areas

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