Prognosis, disease progression, and treatment of atrial fibrillation patients during 1 year: Follow-up of the Euro Heart Survey on Atrial Fibrillation

Robby Nieuwlaat, Martin H. Prins, Jean Yves Le Heuzey, Panos E. Vardas, Etienne Aliot, Massimo Santini, Stuart M. Cobbe, Jos W.M.G. Widdershoven, Leo H. Baur, Samuel Lévy, Harry J.G.M. Crijns, Bertil Olsson, Gu¨nter Breithardt, Malika Manini, Claire Bramley, Vale´rie Laforest, Charles Taylor, Susan Del Gaiso, Kurt Huber, Guy De BackerVera Sirakova, Roman Cerbak, Per Thayssen, Seppo Lehto, Jean Jacques Blanc, Franc¸ois Delahaye, Bondo Kobulia, Uwe Zeymer, Dennis Cokkinos, Kristof Karlocai, Ian Graham, Emer Shelley, Shlomo Behar, Aldo Maggioni, Lino Gonc¸alves, Virginija Grabauskiene, Inger Asmussen, Jaap Deckers, Janina Stepinska, Vyacheslav Mareev, Zorana Vasiljevic, Igor Riecansky, Miran F. Kenda, Angeles Alonso, Jose´ Luis Lopez-Sendon, Annika Rosengren, Peter Buser, Tugrul Okay, Oleg Sychov, Kevin Fox, Peter Schofield, Maarten Simoons, David Wood, Alex Battler, Eric Boersma, Kim Fox, Michel Komajda, Dieter Andresen, Keith McGregor, Barbara Mulder, Sylvia Priori, Lars Ryde´n, Alec Vahanian, William Wijns, Sanofi-Aventis, S. V. Grigoryan, I. Apetyan, S. Aroyan, A. John Camm, L. Azarapetyan, Anahit Anvari, Michael Gottsauner-Wolf, Stefan Pfaffenberger, Kadriye Aydinkoc, Karim Kalla, Martina Penka, Heinz Drexel, Peter Langer, Luc A. Pierard, Wynn Davies, Victor Legrand, Dominique Blommaert, E. Schroeder, Isabelle Mancini, P. Geelen, P. Brugada, Marc De Zutter, Christiaan Vrints, Marc Vercammen, Marielle Morissens, Alessandro Capucci, Boyanov Borisov, Valentin Asenov Petrov, Maria Marinova, Alexandrova Assen, Rachev Goudev, Yavor Peychev, Vassil Stoyanovsky, Evgeni Stoynev, Stjepan Kranjcevic, Joseph Moutiris, Marios Ioannides, Dominique Evequoz, Jaroslava Spacilova, Miroslav Novak, Martin Eisenberger, Jolana Mullerova, Josef Kautzner, Lucie Riedlbauchova, Jan Petru`, Milos Taborsky, Helle Cappelen, Yasser A. Sharaf, B. S.S. Ibrahim, Khalid Tammam, Aly Saad, Helmy Elghawaby, Hamed Zaky Sherif, Heba Farouk, Arlett Mielke, Markus Engelen, Paulus Kirchhof, Pia Zimmermann, F. Fernandez Aviles, Jeronimo Rubio, F. Malpartida, M. Corona, Luis Tercedor Sanchez, Jose Miguel, Lozano Herrera, Aurelio Quesada, Antonio J.Munoz Garcia, Carlos Sanchez Gonzalez, M. Soledad Alcasena Juango, Jesus Berjon-Reyero, Josep M. Alegret, J. M.Cruz Fernandez, Cesar Carrascosa, Rosillo Antonio Fernandez Romero, Miguel Gonza´lez Lara, Jose´ L.Lopez Sendon, Jose´ Juan Gomez de Diego, Luis Sosa Martin, Maria Irurita, Norbero Herrera Guttierez, Juan Ramon Siles Rubio, Isabel Antorrena, Alicia Bautista Paves, Antonio Salvador, Maria Dolores Orriach, A. Alonso Garcia, Francisco Epelde, Vicente Bertomeu Martinez, Antonio Berruezo Sanchez, Carlos Pinero Galvez, Rafael Fernandez Rivero, Antonio Hernandez Madrid, Gonzalo Baron-Esquivias, Rafael Peinado, Jose´ Antonio Gomez Guindal, Tomas Ripoll Vera, Emilio Luengo Fernandez, Ricardo Gayan, Javier Garcia, Andres Bodegas, Jesus Toril Lopez, Julio Martinez Florez, Cristobal Lozano Cabezas, Eduardo Vazquez Ruiz de Castroviejo, Juan Munoz Bellido, Maria Eugenia Ruiz, Kirsti Savolainen, Markku Nieminen, Lauri Toivonen, Mikko Syvanne, Mervi Pietila, Daniel Galley, Christine Beltra, Alain Gay, J. C. Daubert, Guillaume Lecocq, Christine Poulain, J. G.F.C. Cleland, Rhidian Shelton, A. Choudhury, Gulnara Abuladze, Irina Jashi, Anastasia Tsiavou, G. Giamouzis, N. Dagres, A. Kostopoulou, Domproglou Tsoutsanis, C. Stefanadis, George Latsios, Ioannis Vogiatzis, Alexandros Gotsis, Paraskevi Bozia, Maria Karakiriou, Spyridon Koulouris, John Parissis, George Kostakis, Nikos Kouris, Dimitra Kontogianni, Koutroubas Athanasios, Alexandros Douras, Themistoklis Tsanakis, Mary Marketou, Nikolaos Patsourakos, Laszlo Czopf, Robert Halmosi, Istvan Pre´da, Eva Csoti, Andrea Badics, Boris Strasberg, Nahum A. Freedberg, Amos Katz, Eli Zalzstein, Aviva Grosbard, E. Goldhammer, Menachem Nahir, Menashe Epstein, Ida Vider, David Luria, Lori Mandelzweig, Bruno Aloisi, Alfio Cavallaro, Emanuele Antonielli, Baldassarre Doronzo, Diego Pancaldo, Carlo Mazzola, Liliana Buontempi, Valeria Calvi, Giuseppe Giuffrida, Antonino Figlia, Francesco Ippolito, Gian Paolo Gelmini, N. Gaibazzi, Virgilio Ziacchi, Francesco De Tommasi, Federico Lombardi, Cesare Fiorentini, Paolo Terranova, Pietro Maiolino, Muhamad Albunni, Plinio Pinna-Pintor, Stefano Fumagalli, Guilio Masotti, Lorenzo Boncinelli, Domenico Rossi, Giovanni Maria Santoro, Massimo Fioranelli, Franco Naccarella, Stefano Sdringola Maranga, Giovannina Lepera, Barbara Bresciani, Elena Seragnoli, Mara Cantelli Forti, Valentina Cortina, Giacinto Baciarello, Paolo Cicconetti, Antonio Lax, Federica Vitali, Diran Igidbashian, Luisa Scarpino, Sergio Terrazzino, Luigi Tavazzi, Francesco Cantu, Francesco Pentimalli, Salvatore Novo, Giuseppe Coppola, Gianluca Zingarini, Giuseppe Ambrozio, Paolo Moruzzi, Sergio Callegari, Gabriele Saccomanno, Paolo Russo, Emanuele Carbonieri, Anna Paino, Marco Zanetta, Enzo Barducci, Roberto Cemin, Werner Rauhe, Walter Pitscheider, Marina Meloni, Sergio Mariano Marchi, Marco Di Gennaro, Sergio Calcagno, Paola Squaratti, Francesco Quartili, Patrizia Bertocchi, Mario De Martini, Giuseppe Mantovani, Roman Komorovsky, Alessandro Desideri, Leopoldo Celegon, Luigi Tarantini, Giuseppe Catania, Donata Lucci, Francesca Bianchini, Aras Puodziukynas, Ausra Kavoliuniene, Vilija Barauskiene, Audrius Aidietis, Jurate Barysiene, Vitas Vysniauskas, Irena Zukauskiene, Nijole Kazakeviciene, Ljubica Georgievska-Ismail, Lidija Poposka, Eleonora Vataman, Aurel A. Grosu, Wilma Scholte op Reimer, Esther de Swart, Mattie Lenzen, Chris Jansen, Ritzo Brons, Henriette Tebbe, D. C.A. van Hoogenhuyze, M. J. Veerhoek, Maria Kamps, D. Haan, Nitolanda van Rijn, Annette Bootsma, Adrie van den, Heidi Fransen, Luc Eurlings, Joan Meeder, M. J. De Boer, Jobst Winter, Herman Broers, Chris Werter, M. Bijl, Saskia Versluis, Malgorzata Milkowska, Beata Wozakowska-Kaplon, Marianna Janion, Lidia Lepska, Grazyna Swiatecka, Piotr Kokowicz, Jacek Cybulski, Aleksandr Gorecki, Marcin Szulc, Jerzy Rekosz, Rafal Manczak, Anna Maria Wnuk-Wojnar, M. Trusz-Gluza, Anna Rybicka-Musialik, Jaroslaw Myszor, Michal Szpajer, Krzysztof Cymerman, Jerzy Sadowski, Maria Sniezek-Maciejewska, Mariola Ciesla-Dul, Izabela Gorkiewicz-Kot, Tomasz Grodzicki, Krzysztof Rewiuk, Leszek Kubik, Jacek Lewit, Joao Manuel Frazao Rodrigues de Sousa, Rafael Ferreira, Antonio Freitas, Joao Carlos Araujo Morais, Rui Pires, M. J.Veloso Gomes, Paula Gago, Rui Alexandre C. Candeias, Luis Nunes, Joao Vitor Miranda Sa, Miguel Ventura, Mario de Oliveira, Luis Brandao Alves, Ioan Bostaca, Codin T. Olariu, G. A. Dan, Anca Dan, Cristian Podoleanu, Attila Frigy, George I.M. Georgescu, Catalina Arsenescu, Cristian Statescu, Radu Sascau, Dan L. Dimitrascu, Raluca Rancea, Yuri V. Shubik, Dmitry Duplyakov, Marina Shalak, Marine Danielyan, Albert Galyavich, Venera Zakirova, Robert Hatala, Gabriela Kaliska, Jan Kmec, Igor Zupan, Jerneja Tasie`, Damijan Vokac, Nils Edvardsson, Dritan Poci, Habib Gamra, Hichem Denguir, Ahmet Sepetoglu, Alev Arat-Ozkan, Mariya Orynchak, Elena Paliy, I. Vakalyuk, David Malidze, Rostyslav Prog, Myckola Ivanovich Yabluchansky, Nataliya Volodimirovna Makienko, Tatjana Potpara, Sofija Knezevic, Miomir Randjelovic

Research output: Contribution to journalArticlepeer-review

222 Scopus citations

Abstract

Aims: To gain insight in the prognosis and treatment of atrial fibrillation (AF) patients during 1-year follow-up in the Euro Heart Survey (EHS) on AF. Methods and results: The EHS enrolled 5333 AF patients in 2003-2004. One-year follow-up data were available for 80%. Of first detected AF patients, 46% did not have a recurrence during 1 year, paroxysmal AF largely remained paroxysmal AF (80%), and 30% of persistent AF progressed to permanent AF. Many treatment changes occurred since baseline. Oral anticoagulation was started in 19% and discontinued in 16% of all patients. Of patients initially on rhythm control 27% did not receive rhythm control during follow-up, whereas 15% of patients initially on rate control received rhythm control. Mortality was highest in permanent AF (8.2%), but also substantial in first detected AF (5.7%). In multivariable analysis, sinus rhythm at baseline was associated with lower mortality, but no significant effect was observed regarding the application of either rhythm or rate control. Conclusion: The EHS on AF provides unique prospective observational data on AF progression, long-term treatment, prognosis, and determinants of adverse outcome of the total clinical spectrum of AF in a European cardiology-based patient cohort.

Original languageEnglish
Pages (from-to)1181-1189
Number of pages9
JournalEuropean Heart Journal
Volume29
Issue number9
DOIs
StatePublished - 1 May 2008

Keywords

  • Anticoagulation
  • Atrial fibrillation
  • Management
  • Mortality
  • Prognosis
  • Progression
  • Rate control
  • Rhythm control

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