TY - JOUR
T1 - Prognostic significance of granulomas in children with Crohn’s disease
AU - Rothschild, Benjamin
AU - Rinawi, Firas
AU - Herman, Yonatan
AU - Nir, Osnat
AU - Shamir, Raanan
AU - Assa, Amit
N1 - Publisher Copyright:
© 2017 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017/7/3
Y1 - 2017/7/3
N2 - Objectives: Granulomas have long been considered the histological hallmark of Crohn's disease (CD). Currently, there is considerable dispute with regards to their prognostic implications. We aimed to determine the effect of granulomas on phenotypic features and disease's long-term outcomes in a large cohort of pediatric CD patients. Materials and methods: Medical records of pediatric CD patients diagnosed at the Schneider Children’s Medical Center were reviewed retrospectively. Patients were categorized into two groups based on the presence or absence of granulomas at diagnosis. Baseline characteristics included anthropometric, clinical, laboratory, radiological and endoscopic data. Outcome measures included flares, hospitalizations, biological therapy and surgery. Results: Of 289 CD patients diagnosed between 2001 and 2015, 99 patients (34%) had granulomas. Median age of the entire cohort at diagnosis was 14.2 years (females, 42.6%), with a median follow-up of 8.5 years. Patients with granulomas had a significantly higher percentage (47.5% vs. 23.7%, p =.001) of upper gastrointestinal involvement and ileo-colonic disease (64.9% vs. 49.5%, p =.01). Extraintestinal manifestations were twice as common in patients without granulomas (16.3% vs. 8.1%, p =.05). Patients with granulomas were more likely to be hospitalized (HR =1.43, 95% CI: 1.0–2.0) and to receive biologic therapy (HR = 1.52, 95% CI: 1.1–2.11). Additionally, both of these disease outcomes occurred significantly earlier (p =.013 and p =.027, respectively). In contrast, patients with granulomas did not exhibit increased risk of flares or bowel resection. Conclusion: Patients with granulomas exhibited a distinct phenotype at diagnosis and demonstrated a more severe disease course.
AB - Objectives: Granulomas have long been considered the histological hallmark of Crohn's disease (CD). Currently, there is considerable dispute with regards to their prognostic implications. We aimed to determine the effect of granulomas on phenotypic features and disease's long-term outcomes in a large cohort of pediatric CD patients. Materials and methods: Medical records of pediatric CD patients diagnosed at the Schneider Children’s Medical Center were reviewed retrospectively. Patients were categorized into two groups based on the presence or absence of granulomas at diagnosis. Baseline characteristics included anthropometric, clinical, laboratory, radiological and endoscopic data. Outcome measures included flares, hospitalizations, biological therapy and surgery. Results: Of 289 CD patients diagnosed between 2001 and 2015, 99 patients (34%) had granulomas. Median age of the entire cohort at diagnosis was 14.2 years (females, 42.6%), with a median follow-up of 8.5 years. Patients with granulomas had a significantly higher percentage (47.5% vs. 23.7%, p =.001) of upper gastrointestinal involvement and ileo-colonic disease (64.9% vs. 49.5%, p =.01). Extraintestinal manifestations were twice as common in patients without granulomas (16.3% vs. 8.1%, p =.05). Patients with granulomas were more likely to be hospitalized (HR =1.43, 95% CI: 1.0–2.0) and to receive biologic therapy (HR = 1.52, 95% CI: 1.1–2.11). Additionally, both of these disease outcomes occurred significantly earlier (p =.013 and p =.027, respectively). In contrast, patients with granulomas did not exhibit increased risk of flares or bowel resection. Conclusion: Patients with granulomas exhibited a distinct phenotype at diagnosis and demonstrated a more severe disease course.
KW - Biologic treatment
KW - inflammatory bowel disease
KW - pediatric
KW - phenotype
UR - http://www.scopus.com/inward/record.url?scp=85016103169&partnerID=8YFLogxK
U2 - 10.1080/00365521.2017.1304571
DO - 10.1080/00365521.2017.1304571
M3 - Article
C2 - 28346037
AN - SCOPUS:85016103169
SN - 0036-5521
VL - 52
SP - 716
EP - 721
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
IS - 6-7
ER -