Prognostic significance of plasma cell morphology in multiple myeloma

Anna Carter, Irit Hocherman, Shai Linn, Yoram Cohen, Ilana Tatarsky

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

The effect of bone marrow plasma cell morphology at diagnosis on survival time was evaluated in 139 patients with multiple myeloma. According to the morphological classification scheme the patients were categorized as mature (30 patients), immature (76 patients) or plasmablastic (33 patients). The plasmablastic group had an estimated median survival (Kaplan‐Meier method) of 10.9 months, compared with 32.2 months for immature and 60 months for mature types (P = 0.0000). The prognostic value of a morphologic classification in multiple myeloma was further demonstrated by means of a multivariate linear regression analysis of survival data. Expected survival was calculated using clinical features and morphologic subtypes. The estimated survival time for plasmablastic myeloma was shorter by 51.4 months and for immature myeloma patients by 35 months, compared with mature myeloma patients with similar clinical characteristics. Plasma cell morphology at diagnosis is an important predictor of survival duration in patients with multiple myeloma.

Original languageEnglish
Pages (from-to)1060-1065
Number of pages6
JournalCancer
Volume60
Issue number5
DOIs
StatePublished - 1 Jan 1987
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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